CAS 919351-41-0 AZD1283 - Analytical Products / Alfa Chemistry

CAT	AP919351410
CAS	919351-41-0
MDL Number	MFCD26395344
Molecular Weight	470.54

Description	≥98% (HPLC)
Solubility	DMSO: 2 mg/mL, clear
Assay	≥98% (HPLC)
Color	orange to brown
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

Agonist-bound Structure of the Human P2Y12 Receptor

Jin Zhang, Kaihua Zhang, Zhan-Guo Gao, Silvia Paoletta, Dandan Zhang, Gye Won Han, Tingting Li, Limin Ma, Wenru Zhang, Christa E Müller, Huaiyu Yang, Hualiang Jiang, Vadim Cherezov, Vsevolod Katritch, Kenneth A Jacobson, etc.

Nature. 2014 May 1;509(7498):119-22.

PMID: 24784220

1

Lead Optimization of Ethyl 6-aminonicotinate Acyl Sulfonamides as Antagonists of the P2Y12 Receptor. Separation of the Antithrombotic Effect and Bleeding for Candidate Drug AZD1283

Peter Bach, Thomas Antonsson, Ruth Bylund, Jan-Arne Björkman, Krister Österlund, Fabrizio Giordanetto, J J J van Giezen, Søren M Andersen, Helen Zachrisson, Fredrik Zetterberg

J Med Chem. 2013 Sep 12;56(17):7015-24.

PMID: 23899349

1

Optimization of P2Y 12 Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbamoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties

Deyu Kong, Tao Xue, Bin Guo, Jianjun Cheng, Shunyin Liu, Jianhai Wei, Zhengyu Lu, Haoran Liu, Guoqing Gong, Tian Lan, Wenhao Hu, Yushe Yang

J Med Chem. 2019 Mar 28;62(6):3088-3106.

PMID: 30843696

1

Structure of the Human P2Y12 Receptor in Complex With an Antithrombotic Drug

Kaihua Zhang, Jin Zhang, Zhan-Guo Gao, Dandan Zhang, Lan Zhu, Gye Won Han, Steven M Moss, Silvia Paoletta, Evgeny Kiselev, Weizhen Lu, Gustavo Fenalti, Wenru Zhang, Christa E Müller, Huaiyu Yang, Hualiang Jiang, etc.

Nature. 2014 May 1;509(7498):115-8.

PMID: 24670650

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