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BAY 60-7550

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For Research Use Only | Not For Clinical Use
CATAP439083906
CAS439083-90-6
Structure
MDL NumberMFCD08702694
Molecular Weight476.57
Description≥95% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥95% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Inhibition of Phosphodiesterase 2 by Bay 60-7550 Decreases Ethanol Intake and Preference in Mice

Jing Shi, Huaxia Liu, Jianchun Pan, Jie Chen, Nianping Zhang, Kaiping Liu, Ning Fei, James M O'Donnell, Han-Ting Zhang, Ying Xu

Psychopharmacology (Berl). 2018 Aug;235(8):2377-2385.

PMID: 29876622

1

Inhibition of Phosphodiesterase 2 Reverses gp91phox Oxidase-Mediated Depression- And Anxiety-Like Behavior

Xianfeng Huang, Yilixiati Xiaokaiti, Junqing Yang, Jianchun Pan, Zhi Li, Victor Luria, Yunfeng Li, Guoqiang Song, Xiongwei Zhu, Han-Ting Zhang, James M O'Donnell, Ying Xu

Neuropharmacology. 2018 Dec;143:176-185.

PMID: 30268520

1

Phosphodiesterase 2 Inhibition Preferentially Promotes NO/guanylyl cyclase/cGMP Signaling to Reverse the Development of Heart Failure

Reshma S Baliga, Michael E J Preedy, Matthew S Dukinfield, Sandy M Chu, Aisah A Aubdool, Kristen J Bubb, Amie J Moyes, Michael A Tones, Adrian J Hobbs

Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):E7428-E7437.

PMID: 30012589

1

Phosphodiesterase-2 Inhibitor Bay 60-7550 Ameliorates Aβ-Induced Cognitive and Memory Impairment via Regulation of the HPA Axis

Lina Ruan, Kai Du, Mengjia Tao, Chunyan Shan, Ruixuan Ye, Yali Tang, Hanbo Pan, Jinpeng Lv, Meixi Zhang, Jianchun Pan

Front Cell Neurosci. 2019 Oct 2;13:432.

PMID: 31632240

1

The Phosphodiesterase Type 2 Inhibitor BAY 60-7550 Reverses Functional Impairments Induced by Brain Ischemia by Decreasing Hippocampal Neurodegeneration and Enhancing Hippocampal Neuronal Plasticity

Ligia Mendes Soares, Erika Meyer, Humberto Milani, Harry W M Steinbusch, Jos Prickaerts, Rúbia M Weffort de Oliveira

Eur J Neurosci. 2017 Feb;45(4):510-520.

PMID: 27813297

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