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BAY-678

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For Research Use Only | Not For Clinical Use
CATAP675103363
CAS675103-36-3
MDL NumberMFCD29924806
Molecular Weight400.35
InChI KeyPGIVGIFOWOVINL-GOSISDBHSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

Franz von Nussbaum, Volkhart M-J Li, Swen Allerheiligen, Sonja Anlauf, Lars Bärfacker, Martin Bechem, Martina Delbeck, Mary F Fitzgerald, Michael Gerisch, Heike Gielen-Haertwig, Helmut Haning, Dagmar Karthaus, etc.

ChemMedChem. 2015 Jul;10(7):1163-73.

PMID: 26083237

1

Potent and Selective Human Neutrophil Elastase Inhibitors With Novel Equatorial Ring Topology: In Vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model

Franz von Nussbaum, Volkhart M Li, Daniel Meibom, Sonja Anlauf, Martin Bechem, Martina Delbeck, Michael Gerisch, Axel Harrenga, Dagmar Karthaus, Dieter Lang, Klemens Lustig, Joachim Mittendorf, Martina Schäfer, etc.

ChemMedChem. 2016 Jan 19;11(2):199-206.

PMID: 26333652

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