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BAY 87-2243

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For Research Use Only | Not For Clinical Use
CATAP1227158851
CAS1227158-85-1
MDL NumberMFCD28143915
Molecular Weight525.53
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

BAY 87-2243 Sensitizes Hepatocellular Carcinoma Hep3B Cells to Histone Deacetylase Inhibitors Treatment via GSK-3β Activation

Yang-Ling Li, Ming-Jun Rao, Ning-Yu Zhang, Lin-Wen Wu, Neng-Ming Lin, Chong Zhang

Exp Ther Med. 2019 Jun;17(6):4547-4553.

PMID: 31186678

1

BAY 87-2243, a Highly Potent and Selective Inhibitor of Hypoxia-Induced Gene Activation Has Antitumor Activities by Inhibition of Mitochondrial Complex I

Peter Ellinghaus, Iring Heisler, Kerstin Unterschemmann, Michael Haerter, Hartmut Beck, Susanne Greschat, Alexander Ehrmann, Holger Summer, Ingo Flamme, Felix Oehme, Karlheinz Thierauch, Martin Michels, etc.

Cancer Med. 2013 Oct;2(5):611-24.

PMID: 24403227

1

BAY 87-2243, a Novel Inhibitor of Hypoxia-Induced Gene Activation, Improves Local Tumor Control After Fractionated Irradiation in a Schedule-Dependent Manner in Head and Neck Human Xenografts

Linda Helbig, Lydia Koi, Kerstin Brüchner, Kristin Gurtner, Holger Hess-Stumpp, Kerstin Unterschemmann, Michael Baumann, Daniel Zips, Ala Yaromina

Radiat Oncol. 2014 Sep 19;9:207.

PMID: 25234922

1

Mitochondrial Complex I Inhibition Triggers a Mitophagy-Dependent ROS Increase Leading to Necroptosis and Ferroptosis in Melanoma Cells

Farhan Basit, Lisanne Mpe van Oppen, Laura Schöckel, Hasse M Bossenbroek, Sjenet E van Emst-de Vries, Johannes Cw Hermeling, Sander Grefte, Charlotte Kopitz, Melanie Heroult, Peter Hgm Willems, Werner Jh Koopman

Cell Death Dis. 2017 Mar 30;8(3):e2716.

PMID: 28358377

1

Targeting Mitochondrial Complex I Using BAY 87-2243 Reduces Melanoma Tumor Growth

Laura Schöckel, Andrea Glasauer, Farhan Basit, Katharina Bitschar, Hoa Truong, Gerrit Erdmann, Carolyn Algire, Andrea Hägebarth, Peter Hgm Willems, Charlotte Kopitz, Werner Jh Koopman, Mélanie Héroult

Cancer Metab. 2015 Oct 20;3:11.

PMID: 26500770

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