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BC-LI-0186

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For Research Use Only | Not For Clinical Use
CATAP695207568
CAS695207-56-8
Molecular Weight429.53
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Control of Leucine-Dependent mTORC1 Pathway Through Chemical Intervention of leucyl-tRNA Synthetase and RagD Interaction

Jong Hyun Kim, Chulho Lee, Minji Lee, Haipeng Wang, Kibum Kim, Seung Joon Park, Ina Yoon, Jayun Jang, Hanchao Zhao, Hoi Kyoung Kim, Nam Hoon Kwon, Seung Jae Jeong, Hee Chan Yoo, Jae Hyun Kim, Jee Sun Yang, etc.

Nat Commun. 2017 Sep 29;8(1):732.

PMID: 28963468

1

Leucine-induced Localization of Leucyl-tRNA Synthetase in Lysosome Membrane

Hyosun Choi, Jung Bae Son, Jooyoun Kang, Jiwoong Kwon, Jong Hyun Kim, Minkyo Jung, Seong Keun Kim, Sunghoon Kim, Ji Young Mun

Biochem Biophys Res Commun. 2017 Nov 18;493(2):1129-1135.

PMID: 28882589

1

Nontranslational Function of leucyl-tRNA Synthetase Regulates Myogenic Differentiation and Skeletal Muscle Regeneration

Kook Son, Jae-Sung You, Mee-Sup Yoon, Chong Dai, Jong Hyun Kim, Nidhi Khanna, Aditi Banerjee, Susan A Martinis, Gyoonhee Han, Jung Min Han, Sunghoon Kim, Jie Chen

J Clin Invest. 2019 Apr 15;129(5):2088-2093.

PMID: 30985292

1

Therapeutic Effects of the Novel Leucyl-tRNA Synthetase Inhibitor BC-LI-0186 in Non-Small Cell Lung Cancer

Eun Young Kim, Jin Gu Lee, Jung Mo Lee, Arum Kim, Hee Chan Yoo, Kibum Kim, Minji Lee, Chulho Lee, Gyoonhee Han, Jung Min Han, Yoon Soo Chang

Ther Adv Med Oncol. 2019 May 19;11:1758835919846798.

PMID: 31205503

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