CAS 769169-27-9 Begacestat - Analytical Products / Alfa Chemistry

CAT	AP769169279
CAS	769169-27-9
Structure
MDL Number	MFCD18782675
Molecular Weight	391.74
InChI Key	PSXOKXJMVRSARX-SCSAIBSYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: ≥15 mg/mL
Assay	≥98% (HPLC)
Color	white to tan
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

ACS Chemical Neuroscience Molecule Spotlight on Begacestat (GSI-953)

Corey R Hopkins

ACS Chem Neurosci. 2012 Jan 18;3(1):3-4.

PMID: 22860177

1

Begacestat (GSI-953): A Novel, Selective Thiophene Sulfonamide Inhibitor of Amyloid Precursor Protein Gamma-Secretase for the Treatment of Alzheimer's Disease

Robert L Martone, Hua Zhou, Kevin Atchison, Thomas Comery, Jane Z Xu, Xinyi Huang, Xioahai Gong, Mei Jin, Anthony Kreft, Boyd Harrison, Scott C Mayer, Suzan Aschmies, Cathleen Gonzales, Margaret M Zaleska, etc.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608.

PMID: 19671883

1

Computational and In-Vitro Validation of Natural Molecules as Potential Acetylcholinesterase Inhibitors and Neuroprotective Agents

Ashwani Kumar, Vineet Mehta, Utkarsh Raj, Pritish Kumar Varadwaj, Malairaman Udayabanu, Ragothaman M Yennamalli, Tiratha Raj Singh

Curr Alzheimer Res. 2019;16(2):116-127.

PMID: 30543170

1

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-secretase Inhibitors That Selectively Inhibit the Production of amyloid-β Over Notch

Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Roy K Hom, Andrei W Konradi, Jennifer L Marugg, Matthew N Mattson, Martin L Neitzel, Chris M Semko, Hing L Sham, Jenifer Smith, etc.

J Med Chem. 2013 Jul 11;56(13):5261-74.

PMID: 23713656

1

Discovery of Begacestat, a Notch-1-sparing Gamma-Secretase Inhibitor for the Treatment of Alzheimer's Disease

Scott C Mayer, Anthony F Kreft, Boyd Harrison, Magid Abou-Gharbia, Madelene Antane, Suzan Aschmies, Kevin Atchison, Michael Chlenov, Derek C Cole, Thomas Comery, George Diamantidis, John Ellingboe, Kristi Fan, etc.

J Med Chem. 2008 Dec 11;51(23):7348-51.

PMID: 19012391

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