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BH3I-1

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For Research Use Only | Not For Clinical Use
CATAP300817689
CAS300817-68-9
Structure
MDL NumberMFCD03453544
Molecular Weight400.31
InChI KeyCOHIEJLWRGREHV-YRNVUSSQSA-N
Description≥97% (HPLC), powder, yellow
SolubilityDMSO: soluble >10 mg/mL; H2O: insoluble
Assay≥97% (HPLC)
Formpowder, yellow
Size5MG
Storage Conditions2-8°C
1

Bcl-2 Overexpression in Thyroid Carcinoma Cells Increases Sensitivity to Bcl-2 Homology 3 Domain Inhibition

Constantine S Mitsiades, Patrick Hayden, Vassiliki Kotoula, Douglas W McMillin, Ciaran McMullan, Joseph Negri, Jake E Delmore, Vassiliki Poulaki, Nicholas Mitsiades

J Clin Endocrinol Metab. 2007 Dec;92(12):4845-52.

PMID: 17848408

1

Enhancement of Radiation Sensitivity With BH3I-1 in Non-Small Cell Lung Cancer

W Roa, H Chen, A Alexander, S Gulavita, J Thng, X J Sun, K Petruk, R Moore

Clin Invest Med. 2005 Apr;28(2):55-63.

PMID: 15909480

1

Inhibition of Yeast-To-Filamentous Growth Transitions in Candida Albicans by a Small Molecule Inducer of Mammalian Apoptosis

Joy Goffena, Kurt A Toenjes, David K Butler

Yeast. 2018 Mar;35(3):291-298.

PMID: 29048745

1

Profiling Small Molecule Inhibitors Against Helix-Receptor Interactions: The Bcl-2 Family Inhibitor BH3I-1 Potently Inhibits p53/hDM2

Jason R Porter, Mark R Helmers, Ping Wang, Jennifer L Furman, Stephen T Joy, Paramjit S Arora, Indraneel Ghosh

Chem Commun (Camb). 2010 Nov 14;46(42):8020-2.

PMID: 20856941

1

The BH3 Mimetic Compound BH3I-1 Impairs Mitochondrial Dynamics and Promotes Stress Response in Addition to Its Pro-Apoptotic Key Function

David Stucki, Peter Brenneisen, Andreas S Reichert, Wilhelm Stahl

Toxicol Lett. 2018 Oct 1;295:369-378.

PMID: 30031050

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