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BL-1249

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For Research Use Only | Not For Clinical Use
CATAP18200130
CAS18200-13-0
MDL NumberMFCD08276915
Molecular Weight291.35
InChI KeyYYNRZIFBTOUICE-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: ~17.5 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Colorpink to brown
Formsolid
Size10MG, 50MG
Storage Conditions−20°C
1

Arachidonic Acid Hyperpolarizes Mesenchymal Stromal Cells From the Human Adipose Tissue by Stimulating TREK1 K

Michail V Tarasov, Polina D Kotova, Marina F Bystrova, Natalia V Kabanova, Veronika Yu Sysoeva, Stanislav S Kolesnikov

Channels (Austin). 2019 Dec;13(1):36-47.

PMID: 30661462

1

BL-1249 [(5,6,7,8-tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener With Bladder-Relaxant Properties

Svetlana Tertyshnikova, Ronald J Knox, Mary Jane Plym, George Thalody, Corinne Griffin, Torben Neelands, David G Harden, Laura Signor, David Weaver, Robert A Myers, Nicholas J Lodge

J Pharmacol Exp Ther. 2005 Apr;313(1):250-9.

PMID: 15608074

1

Pranlukast Is a Novel Small Molecule Activator of the Two-Pore Domain Potassium Channel TREK2

Paul D Wright, David McCoull, Yvonne Walsh, Jonathan M Large, Barbara W Hadrys, Egle Gaurilcikaite, Lewis Byrom, Emma L Veale, Jeff Jerman, Alistair Mathie

Biochem Biophys Res Commun. 2019 Nov 26;520(1):35-40.

PMID: 31564414

1

Protein and Chemical Determinants of BL-1249 Action and Selectivity for K 2P Channels

Lianne Pope, Cristina Arrigoni, Hubing Lou, Clifford Bryant, Alejandra Gallardo-Godoy, Adam R Renslo, Daniel L Minor Jr

ACS Chem Neurosci. 2018 Dec 19;9(12):3153-3165.

PMID: 30089357

1

Towards a TREK-1/2 (TWIK-Related K+ Channel 1 and 2) Dual Activator Tool Compound: Multi-dimensional Optimization of BL-1249

Yuzo Iwaki, Kentaro Yashiro, Masaya Kokubo, Takahiro Mori, Joshua M Wieting, Kevin M McGowan, Thomas M Bridges, Darren W Engers, Jerod S Denton, Haruto Kurata, Craig W Lindsley

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1601-1604.

PMID: 31072652

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