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BMS-191011

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For Research Use Only | Not For Clinical Use
CATAP202821816
CAS202821-81-6
Structure
Molecular Weight370.71
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: Opener of Large-Conductance Ca(2+)-activated Potassium (maxi-K) Channels, Identification, Solubility, and SAR

Jeffrey L Romine, Scott W Martin, Nicholas A Meanwell, Valentin K Gribkoff, Christopher G Boissard, Steven I Dworetzky, Joanne Natale, Sandra Moon, Astrid Ortiz, Swamy Yeleswaram, Lorraine Pajor, Qi Gao, etc.

J Med Chem. 2007 Feb 8;50(3):528-42.

PMID: 17266205

1

Apelin Reduces Nitric Oxide-Induced Relaxation of Cerebral Arteries by Inhibiting Activation of Large-Conductance, Calcium-Activated K Channels

Amreen Mughal, Chengwen Sun, Stephen T OʼRourke

J Cardiovasc Pharmacol. 2018 Apr;71(4):223-232.

PMID: 29620606

1

BMS-191011, an Opener of Large-Conductance Ca2+-activated Potassium Channels, Dilates Rat Retinal Arterioles in Vivo

Asami Mori, Sachi Suzuki, Kenji Sakamoto, Tsutomu Nakahara, Kunio Ishii

Biol Pharm Bull. 2011;34(1):150-2.

PMID: 21212534

1

Methylglyoxal Impairs β 2-Adrenoceptor-Mediated Vasodilatory Mechanisms in Rat Retinal Arterioles

Mari Akagawa, Asami Mori, Kenji Sakamoto, Tsutomu Nakahara

Biol Pharm Bull. 2018;41(2):272-276.

PMID: 29386487

1

Synthesis of Water-Soluble Prodrugs of BMS-191011: A maxi-K Channel Opener Targeted for Post-Stroke Neuroprotection

Piyasena Hewawasam, Min Ding, Nathan Chen, Dalton King, Jay Knipe, Lorraine Pajor, Astrid Ortiz, Valentin K Gribkoff, John Starrett

Bioorg Med Chem Lett. 2003 May 19;13(10):1695-8.

PMID: 12729644

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