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BMS-193885

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For Research Use Only | Not For Clinical Use
CATAP186185035
CAS186185-03-5
Structure
MDL NumberMFCD16878998
Molecular Weight590.71
InChI KeyWMYSXJSJXZFODY-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: >10 mg/mL
Assay≥98% (HPLC)
Colorlight yellow to yellow
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Dihydropyridine Neuropeptide Y Y1 Receptor Antagonists 2. Bioisosteric Urea Replacements

Graham S Poindexter, Marc A Bruce, J Guy Breitenbucher, Mendi A Higgins, S-Y Sit, Jeffrey L Romine, Scott W Martin, Sally A Ward, Rachel T McGovern, Wendy Clarke, John Russell, Ildiko Antal-Zimanyi

Bioorg Med Chem. 2004 Jan 15;12(2):507-21.

PMID: 14723969

1

Orexin-A Signaling in the Paraventricular Nucleus Modulates Spontaneous Firing of Glucose-Sensitive Neurons and Promotes Food Intake via the NPY Pathway in Rats

Cheng Wang, Xiaohua Han, Feifei Guo, Xiangrong Sun, Xiao Luan, Luo Xu

Biochem Biophys Res Commun. 2018 Oct 20;505(1):162-167.

PMID: 30243725

1

Pharmacological Characterization and Appetite Suppressive Properties of BMS-193885, a Novel and Selective Neuropeptide Y(1) Receptor Antagonist

Ildiko Antal-Zimanyi, Marc A Bruce, Karen L Leboulluec, Lawrence G Iben, Gail K Mattson, Rachel T McGovern, John B Hogan, Christina L Leahy, Sharon C Flowers, Jennifer A Stanley, Astrid A Ortiz, Graham S Poindexter

Eur J Pharmacol. 2008 Aug 20;590(1-3):224-32.

PMID: 18573246

1

Radiosynthesis and in vivo evaluation of 11 C-labeled BMS-193885 and its desmethyl analog as PET tracers for neuropeptide Y1 receptors

Kazunori Kawamura, Wakana Mori, Masayuki Fujinaga, Tomoteru Yamasaki, Yiding Zhang, Hidekatsu Wakizaka, Akiko Hatori, Lin Xie, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, etc.

EJNMMI Radiopharm Chem. 2019 Feb 18;4(1):4.

PMID: 31659508

1

Structural basis of ligand binding modes at the neuropeptide Y Y 1 receptor

Zhenlin Yang, Shuo Han, Max Keller, Anette Kaiser, Brian J Bender, Mathias Bosse, Kerstin Burkert, Lisa M Kögler, David Wifling, Guenther Bernhardt, Nicole Plank, Timo Littmann, Peter Schmidt, Cuiying Yi, etc.

Nature. 2018 Apr;556(7702):520-524.

PMID: 29670288

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