CAS 290315-45-6 BMS-299897 - Analytical Products / Alfa Chemistry

CAT	AP290315456
CAS	290315-45-6
Molecular Weight	511.94

Description	≥98% (HPLC)
Solubility	DMSO: ≥20 mg/mL
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

1

In Vitro and in Vivo Metabolism of a Gamma-Secretase Inhibitor BMS-299897 and Generation of Active Metabolites in Milligram Quantities With a Microbial Bioreactor

Donglu Zhang, Ronald Hanson, Vikram Roongta, Douglas D Dischino, Qi Gao, Charles P Sloan, Craig Polson, Daniel Keavy, Ming Zheng, James Mitroka, Suresh Yeola

Curr Drug Metab. 2006 Dec;7(8):883-96.

PMID: 17168689

1

Liquid-liquid Extraction of Strongly Protein Bound BMS-299897 From Human Plasma and Cerebrospinal Fluid, Followed by High-Performance Liquid chromatography/tandem Mass Spectrometry

Y J Xue, Janice Pursley, Mark Arnold

J Pharm Biomed Anal. 2007 Apr 11;43(5):1728-36.

PMID: 17204392

1

Reductions in Beta-Amyloid Concentrations in Vivo by the Gamma-Secretase Inhibitors BMS-289948 and BMS-299897

Jeffery J Anderson, Greg Holtz, Patricia P Baskin, Mary Turner, Blake Rowe, Bowei Wang, Maria Z Kounnas, Bruce T Lamb, Donna Barten, Kevin Felsenstein, Ian McDonald, Kumar Srinivasan, Ben Munoz, Steven L Wagner

Biochem Pharmacol. 2005 Feb 15;69(4):689-98.

PMID: 15670587

1

Studies on the Pharmacokinetics and Metabolism of a Gamma-Secretase Inhibitor BMS-299897, and Exploratory Investigation of CYP Enzyme Induction

M Zheng, J Wang, J Lubinski, O P Flint, R Krishna, M Yao, J M Pursley, A Thakur, D W Boulton, K S Santone, D M Barten, J J Anderson, K M Felsenstein, S B Hansel

Xenobiotica. 2009 Jul;39(7):544-55.

PMID: 19480557

1

The γ-secretase Inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic Acid (BMS-299897) Alleviates Aβ1-42 Seeding and Short-Term Memory Deficits in the Aβ25-35 Mouse Model of Alzheimer's Disease

Johann Meunier, Vanessa Villard, Laurent Givalois, Tangui Maurice

Eur J Pharmacol. 2013 Jan 5;698(1-3):193-9.

PMID: 23123349

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