BMS-599626

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For Research Use Only | Not For Clinical Use

CAT	AP714971092
CAS	714971-09-2
MDL Number	MFCD10565678
Molecular Weight	530.55
InChI Key	LUJZZYWHBDHDQX-QFIPXVFZSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	−20°C

AC480, Formerly BMS-599626, a Pan Her Inhibitor, Enhances Radiosensitivity and Radioresponse of Head and Neck Squamous Cell Carcinoma Cells in Vitro and in Vivo

Mylin A Torres, Uma Raju, David Molkentine, Oliver Riesterer, Luka Milas, K Kian Ang

Invest New Drugs. 2011 Aug;29(4):554-61.

PMID: 20119866

Phase I Safety, Pharmacokinetic and Pharmacodynamic Trial of BMS-599626 (AC480), an Oral pan-HER Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced Solid Tumors

J-C Soria, J Cortes, C Massard, J-P Armand, D De Andreis, S Ropert, E Lopez, A Catteau, J James, J-F Marier, M Beliveau, R E Martell, J Baselga

Ann Oncol. 2012 Feb;23(2):463-71.

PMID: 21576284

Preclinical Antitumor Activity of BMS-599626, a pan-HER Kinase Inhibitor That Inhibits HER1/HER2 Homodimer and Heterodimer Signaling

Tai W Wong, Francis Y Lee, Chiang Yu, Feng R Luo, Simone Oppenheimer, Hongjian Zhang, Richard A Smykla, Harold Mastalerz, Brian E Fink, John T Hunt, Ashvinikumar V Gavai, Gregory D Vite

Clin Cancer Res. 2006 Oct 15;12(20 Pt 1):6186-93.

PMID: 17062696

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