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BMS-906024

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For Research Use Only | Not For Clinical Use
CATAP1401066792
CAS1401066-79-2
MDL NumberMFCD24849414
Molecular Weight556.50
InChI KeyAYOUDDAETNMCBW-GSHUGGBRSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG
Storage Conditionsroom temp
1

Complete Hematologic Response of Early T-cell Progenitor Acute Lymphoblastic Leukemia to the γ-secretase Inhibitor BMS-906024: Genetic and Epigenetic Findings in an Outlier Case

Birgit Knoechel, Ami Bhatt, Li Pan, Chandra S Pedamallu, Eric Severson, Alejandro Gutierrez, David M Dorfman, Frank C Kuo, Michael Kluk, Andrew L Kung, Patrick Zweidler-McKay, Matthew Meyerson, Stephen C Blacklow, etc.

Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000539.

PMID: 27148573

1

Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors

Ashvinikumar V Gavai, Claude Quesnelle, Derek Norris, Wen-Ching Han, Patrice Gill, Weifang Shan, Aaron Balog, Ke Chen, Andrew Tebben, Richard Rampulla, Dauh-Rurng Wu, Yingru Zhang, Arvind Mathur, Ronald White, etc.

ACS Med Chem Lett. 2015 Mar 11;6(5):523-7.

PMID: 26005526

1

Gamma Secretase Inhibition by BMS-906024 Enhances Efficacy of Paclitaxel in Lung Adenocarcinoma

Katherine M Morgan, Bruce S Fischer, Francis Y Lee, Jamie J Shah, Joseph R Bertino, Jeffrey Rosenfeld, Amartya Singh, Hossein Khiabanian, Sharon R Pine

Mol Cancer Ther. 2017 Dec;16(12):2759-2769.

PMID: 28978720

1

Synergistic Effects of NOTCH/γ-Secretase Inhibition and Standard of Care Treatment Modalities in Non-small Cell Lung Cancer Cells

Venus Sosa Iglesias, Jan Theys, Arjan J Groot, Lydie M O Barbeau, Alyssa Lemmens, Ala Yaromina, Mario Losen, Ruud Houben, Ludwig Dubois, Marc Vooijs

Front Oncol. 2018 Nov 7;8:460.

PMID: 30464927

1

Utilizing Internal Standard Responses to Assess Risk on Reporting Bioanalytical Results From Hemolyzed Samples

Eliza N Fung, Anne-Françoise Aubry, Alban Allentoff, Qin C Ji

AAPS J. 2015 Sep;17(5):1168-76.

PMID: 25975617

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