CAS 433695-36-4 BRL 50481 - Analytical Products / Alfa Chemistry

CAT	AP433695364
CAS	433695-36-4
Structure
MDL Number	MFCD03039912
Molecular Weight	244.27
InChI Key	IFIUFCJFLGCQPH-UHFFFAOYSA-N

Description	≥98% (HPLC), solid
Solubility	DMSO: >10 mg/mL; H2O: insoluble
Assay	≥98% (HPLC)
Color	white to off-white
Form	solid
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Characterization of Renal Ecto-Phosphodiesterase

Edwin K Jackson, Jin Ren, Lefteris C Zacharia, Zaichuan Mi

J Pharmacol Exp Ther. 2007 May;321(2):810-5.

PMID: 17308037

1

Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-lymphocytes

Susan J Smith, Lenora B Cieslinski, Robert Newton, Louise E Donnelly, Peter S Fenwick, Andrew G Nicholson, Peter J Barnes, Mary S Barnette, Mark A Giembycz

Mol Pharmacol. 2004 Dec;66(6):1679-89.

PMID: 15371556

1

Novel Amide Derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic Acids as Multifunctional TRPA1 Antagonists and PDE4/7 Inhibitors: A New Approach for the Treatment of Pain

Grażyna Chłoń-Rzepa, Marietta Ślusarczyk, Agnieszka Jankowska, Alicja Gawalska, Adam Bucki, Marcin Kołaczkowski, Artur Świerczek, Krzysztof Pociecha, Elżbieta Wyska, Małgorzata Zygmunt, Grzegorz Kazek, etc.

Eur J Med Chem. 2018 Oct 5;158:517-533.

PMID: 30245393

1

Novel Butanehydrazide Derivatives of purine-2,6-dione as Dual PDE4/7 Inhibitors With Potential Anti-Inflammatory Activity: Design, Synthesis and Biological Evaluation

Grażyna Chłoń-Rzepa, Agnieszka Jankowska, Marietta Ślusarczyk, Artur Świerczek, Krzysztof Pociecha, Elżbieta Wyska, Adam Bucki, Alicja Gawalska, Marcin Kołaczkowski, Maciej Pawłowski

Eur J Med Chem. 2018 Feb 25;146:381-394.

PMID: 29407965

1

PDE-7 Inhibitor BRL-50481 Reduces Neurodegeneration and Long-Term Memory Deficits in Mice Following Sevoflurane Exposure

Yingle Chen, Shunyuan Li, Xianmei Zhong, Zhenming Kang, Rulei Chen

ACS Chem Neurosci. 2020 May 6;11(9):1353-1358.

PMID: 32271540

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