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Bromosporine

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For Research Use Only | Not For Clinical Use
CATIAR4242523
MDL NumberMFCD26142669
Molecular Weight404.44
InChI KeyUYBRROMMFMPJAN-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

Thomas C Roberts, Usue Etxaniz, Alessandra Dall'Agnese, Shwu-Yuan Wu, Cheng-Ming Chiang, Paul E Brennan, Matthew J A Wood, Pier Lorenzo Puri

Sci Rep. 2017 Jul 21;7(1):6153.

PMID: 28733670

1

Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells

Xin Li, Yizhe Wu, Gaofei Tian, Yixiang Jiang, Zheng Liu, Xianbin Meng, Xiucong Bao, Ling Feng, Hongyan Sun, Haiteng Deng, Xiang David Li

J Am Chem Soc. 2019 Jul 24;141(29):11497-11505.

PMID: 31246451

1

Epigenetic Drug Screen Identifies the Histone Deacetylase Inhibitor NSC3852 as a Potential Novel Drug for the Treatment of Pediatric Acute Myeloid Leukemia

Caroline R M Wiggers, Anita M A P Govers, Daphne Lelieveld, David A Egan, C Michel Zwaan, Edwin Sonneveld, Paul J Coffer, Marije Bartels

Pediatr Blood Cancer. 2019 Aug;66(8):e27785.

PMID: 31044544

1

Promiscuous Targeting of Bromodomains by Bromosporine Identifies BET Proteins as Master Regulators of Primary Transcription Response in Leukemia

Sarah Picaud, Katharina Leonards, Jean-Philippe Lambert, Oliver Dovey, Christopher Wells, Oleg Fedorov, Octovia Monteiro, Takao Fujisawa, Chen-Yi Wang, Hannah Lingard, Cynthia Tallant, Nikzad Nikbin, Lucie Guetzoyan, etc.

Sci Adv. 2016 Oct 12;2(10):e1600760.

PMID: 27757418

1

The Bromodomain and Extraterminal Domain Inhibitor Bromosporine Synergistically Reactivates Latent HIV-1 in Latently Infected Cells

Hanyu Pan, Panpan Lu, Yinzhong Shen, Yanan Wang, Zhengtao Jiang, Xinyi Yang, Yangcheng Zhong, He Yang, Inam Ulla Khan, Muya Zhou, Bokang Li, Ziyu Zhang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Oncotarget. 2017 Oct 6;8(55):94104-94116.

PMID: 29212213

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