CAS 178946-89-9 C-DIM12 - Analytical Products / Alfa Chemistry

CAT	AP178946899
CAS	178946-89-9
Molecular Weight	356.85
InChI Key	LTLRXTDMXOFBDW-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: 20 mg/mL, clear
Assay	≥98% (HPLC)
Color	, light orange to dark red
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

A Novel Diindolylmethane Analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane, Inhibits the Tumor Necrosis Factor-Induced Inflammatory Response in Primary Murine Synovial Fibroblasts Through a Nurr1-dependent Mechanism

Maryam F Afzali, Katriana A Popichak, Lindsey H Burton, Anna L Klochak, William J Wilson, Stephen Safe, Ronald B Tjalkens, Marie E Legare

Mol Immunol. 2018 Sep;101:46-54.

PMID: 29870816

1

A Novel Synthetic Activator of Nurr1 Induces Dopaminergic Gene Expression and Protects Against 6-hydroxydopamine Neurotoxicity in Vitro

Sean L Hammond, Stephen Safe, Ronald B Tjalkens

Neurosci Lett. 2015 Oct 21;607:83-89.

PMID: 26383113

1

Neuroprotective Efficacy and Pharmacokinetic Behavior of Novel Anti-Inflammatory Para-Phenyl Substituted Diindolylmethanes in a Mouse Model of Parkinson's Disease

Briana R De Miranda, James A Miller, Ryan J Hansen, Paul J Lunghofer, Stephen Safe, Daniel L Gustafson, Dorothy Colagiovanni, Ronald B Tjalkens

J Pharmacol Exp Ther. 2013 Apr;345(1):125-38.

PMID: 23318470

1

The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB

Briana R De Miranda, Katriana A Popichak, Sean L Hammond, Bryce A Jorgensen, Aaron T Phillips, Stephen Safe, Ronald B Tjalkens

Mol Pharmacol. 2015 Jun;87(6):1021-34.

PMID: 25858541

1

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-( p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism

Sean L Hammond, Katriana A Popichak, Xi Li, Lindsay G Hunt, Evan H Richman, Pranav U Damale, Edwin K P Chong, Donald S Backos, Stephen Safe, Ronald B Tjalkens

J Pharmacol Exp Ther. 2018 Jun;365(3):636-651.

PMID: 29626009

* Products or Services Interested: C-DIM12 (178946-89-9)
* Your question
* Name
* Email
Verification Code