c-Raf Inhibitor - Analytical Products / Alfa Chemistry

CAT	IAR42417855
Molecular Weight	480.45

Description	The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Solubility	DMSO: 10 mg/mL
Assay	≥95% (HPLC)
Color	off-white
Form	solid
Size	20MG
Storage Conditions	+2C to +8C

1

[Mechanism Underlying Pancreatic Cancer Cell Resistance to mTOR Inhibitor RAD001 via c-Raf/ERK1/2 Activation]

Feng Wei, Ping Zhang, Jun Qi, Meng Wang, Guangyi Wang

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jan;30(1):23-7.

PMID: 24405594

1

Effect of SB 203580 on the Activity of c-Raf in Vitro and in Vivo

C A Hall-Jackson, M Goedert, P Hedge, P Cohen

Oncogene. 1999 Mar 25;18(12):2047-54.

PMID: 10321729

1

GW5074 and PP2 Kinase Inhibitors Implicate Nontraditional c-Raf and Lyn Function as Drivers of Retinoic Acid-Induced Maturation

Holly A Jensen, Rodica P Bunaciu, Jeffrey D Varner, Andrew Yen

Cell Signal. 2015 Aug;27(8):1666-75.

PMID: 25817574

1

Protein Kinase C Alpha Trigger Ras and Raf-independent MEK/ERK Activation for TPA-induced Growth Inhibition of Human Hepatoma Cell HepG2

Wu Wen-Sheng

Cancer Lett. 2006 Jul 28;239(1):27-35.

PMID: 16169661

1

The c-Raf Inhibitor GW5074 Provides Neuroprotection in Vitro and in an Animal Model of Neurodegeneration Through a MEK-ERK and Akt-independent Mechanism

Paul C Chin, Li Liu, Bradley E Morrison, Ambreena Siddiq, Rajiv R Ratan, Teodoro Bottiglieri, Santosh R D'Mello

J Neurochem. 2004 Aug;90(3):595-608.

PMID: 15255937

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