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Calpastatin Peptide

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For Research Use Only | Not For Clinical Use
CATIAR42415262
Molecular Weight3177.63
DescriptionA 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC₅₀ = 20 nM for purified rabbit calpain II).
Solubility1% acetic acid: 1 mg/mL; water: 1 mg/mL
Assay≥95% (HPLC)
Colorwhite
Formlyophilized solid; desiccated
Size500μG
Storage Conditions-20C
1

A Structural Model for the Inhibition of Calpain by Calpastatin: Crystal Structures of the Native Domain VI of Calpain and Its Complexes With Calpastatin Peptide and a Small Molecule Inhibitor

Bice Todd, Dwight Moore, Champion C S Deivanayagam, Guang-da Lin, Debasish Chattopadhyay, Masatoshi Maki, Kevin K W Wang, Sthanam V L Narayana

J Mol Biol. 2003 Apr 18;328(1):131-46.

PMID: 12684003

1

Calpastatin Peptide Attenuates Early Brain Injury Following Experimental Subarachnoid Hemorrhage

Fei Teng, Yanxin Yin, Jia Guo, Ming Jiang

Exp Ther Med. 2020 Apr;19(4):2433-2440.

PMID: 32226486

1

Involvement of Calpain-Calpastatin in Cigarette Smoke-Induced Inhibition of Lung Endothelial Nitric Oxide Synthase

Zhaoqiang Cui, Zhaosheng Han, Zhaozhong Li, Hanbo Hu, Jawaharlal M Patel, Veena Antony, Edward R Block, Yunchao Su

Am J Respir Cell Mol Biol. 2005 Nov;33(5):513-20.

PMID: 16100081

1

Poly-arginine-fused Calpastatin Peptide, a Living Cell Membrane-Permeable and Specific Inhibitor for Calpain

Hai-Yan Wu, Kazuhito Tomizawa, Masayuki Matsushita, Yun-Fei Lu, Sheng-Tian Li, Hideki Matsui

Neurosci Res. 2003 Sep;47(1):131-5.

PMID: 12941454

1

Structural Determinants of the Calpain Inhibitory Activity of Calpastatin Peptide B27-WT

Russell Betts, Shantel Weinsheimer, Grant E Blouse, John Anagli

J Biol Chem. 2003 Mar 7;278(10):7800-9.

PMID: 12500971

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