CAS 101932-71-2 Calyculin A from Discodermia calyx - Analytical Products / Alfa Chemistry

CAT	AP101932712
CAS	101932-71-2
Structure
MDL Number	MFCD06795864
Molecular Weight	1009.17
InChI Key	FKAWLXNLHHIHLA-YCBIHMBMSA-N
REAXYS Number	4903216

Description	≥90% (HPLC), solid
Solubility	DMSO: soluble; ethanol: soluble
Assay	≥90% (HPLC)
Color	white
Form	solid
Size	10UG
Storage Conditions	−20°C

1

Calyculin A From Discodermia Calyx Is a Dual Action Toxin That Blocks Calcium Influx and Inhibits Protein Ser/Thr Phosphatases

Maja Holy, David L Brautigan

Toxins (Basel). 2012 Oct;4(10):940-54.

PMID: 23162706

1

Calyculin Biogenesis From a Pyrophosphate Protoxin Produced by a Sponge Symbiont

Toshiyuki Wakimoto, Yoko Egami, Yu Nakashima, Yukihiko Wakimoto, Takahiro Mori, Takayoshi Awakawa, Takuya Ito, Hiromichi Kenmoku, Yoshinori Asakawa, Jörn Piel, Ikuro Abe

Nat Chem Biol. 2014 Aug;10(8):648-55.

PMID: 24974231

1

Insight Into Binding of Calyculin A to Protein Phosphatase 1: Isolation of Hemicalyculin a and Chemical Transformation of Calyculin A

Toshiyuki Wakimoto, Shigeki Matsunaga, Akira Takai, Nobuhiro Fusetani

Chem Biol. 2002 Mar;9(3):309-19.

PMID: 11927256

1

Phosphocalyculin C as a Pyrophosphate Protoxin of Calyculin C in the Marine Sponge Discodermia Calyx

Yoko Egami, Toshiyuki Wakimoto, Ikuro Abe

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5150-3.

PMID: 25442302

1

The Discodermia Calyx Toxin Calyculin a Enhances Cyclin D1 Phosphorylation and Degradation, and Arrests Cell Cycle Progression in Human Breast Cancer Cells

Jessica R Edelson, David L Brautigan

Toxins (Basel). 2011 Jan;3(1):105-19.

PMID: 22069692

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