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Carmofur

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For Research Use Only | Not For Clinical Use
CATAP61422455
CAS61422-45-5
Structure
MDL NumberMFCD00866284
Molecular Weight257.26
InChI KeyAOCCBINRVIKJHY-UHFFFAOYSA-N
Description≥98% (HPLC), powder
SolubilityDMSO: >15 mg/mL
Assay≥98% (HPLC)
Colorwhite to off-white
Formpowder
Size10MG, 50MG
Storage Conditions2-8°C
1

A New Use for an Old Drug: Carmofur Attenuates Lipopolysaccharide (LPS)-Induced Acute Lung Injury

Kangni Wu, Yanghui Xiu, Pan Zhou, Yan Qiu, Yuhang Li

Front Pharmacol. 2019 Jul 19;10:818.

PMID: 31379583

1

Acid Ceramidase Inhibition Ameliorates α-synuclein Accumulation Upon Loss of GBA1 Function

Myung Jong Kim, Sohee Jeon, Lena F Burbulla, Dimitri Krainc

Hum Mol Genet. 2018 Jun 1;27(11):1972-1988.

PMID: 29579237

1

Control of Lysosomal TRPML1 Channel Activity and Exosome Release by Acid Ceramidase in Mouse Podocytes

Guangbi Li, Dandan Huang, Jinni Hong, Owais M Bhat, Xinxu Yuan, Pin-Lan Li

Am J Physiol Cell Physiol. 2019 Sep 1;317(3):C481-C491.

PMID: 31268777

1

Genetic Ablation of Acid Ceramidase in Krabbe Disease Confirms the Psychosine Hypothesis and Identifies a New Therapeutic Target

Yedda Li, Yue Xu, Bruno A Benitez, Murtaza S Nagree, Joshua T Dearborn, Xuntian Jiang, Miguel A Guzman, Josh C Woloszynek, Alex Giaramita, Bryan K Yip, Joseph Elsbernd, Michael C Babcock, Melanie Lo, Stephen C Fowler, etc.

Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20097-20103.

PMID: 31527255

1

Molecular Mechanism of Inhibition of Acid Ceramidase by Carmofur

Alexey Dementiev, Andrzej Joachimiak, Ha Nguyen, Alexei Gorelik, Katalin Illes, Saman Shabani, Michael Gelsomino, Eun-Young Erin Ahn, Bhushan Nagar, Ninh Doan

J Med Chem. 2019 Jan 24;62(2):987-992.

PMID: 30525581

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