CAS 9064-57-7 λ-Carrageenan - Analytical Products / Alfa Chemistry

CAT	AP9064577
CAS	9064-57-7
MDL Number	MFCD00151513
EC Number	232-953-5

Description	plant mucopolysaccharide
Size	5G, 25G
Storage Conditions	room temp

Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy

Min Luo, Bin Shao, Wen Nie, Xia-Wei Wei, Yu-Li Li, Bi-Lan Wang, Zhi-Yao He, Xiao Liang, Ting-Hong Ye, Yu-Quan Wei

Sci Rep. 2015 Jun 22;5:11062.

PMID: 26098663

Specific Binding of Trivalent Metal Ions to λ-carrageenan

Yiping Cao, Shugang Li, Yapeng Fang, Katsuyoshi Nishinari, Glyn O Phillips, Adrien Lerbret, Ali Assifaoui

Int J Biol Macromol. 2018 Apr 1;109:350-356.

PMID: 29269011

λ-Carrageenan Improves the Antitumor Effect of Dendritic Cellbased Vaccine

Jinyao Li, Adila Aipire, Jinyu Li, Hongge Zhu, Yanping Wang, Wenjia Guo, Xiaoqin Li, Jia Yang, Chunling Liu

Oncotarget. 2017 May 2;8(18):29996-30007.

PMID: 28404904

λ-Carrageenan Oligosaccharides of Distinct Anti-Heparanase and Anticoagulant Activities Inhibit MDA-MB-231 Breast Cancer Cell Migration

Hugo Groult, Rémi Cousin, Caroline Chot-Plassot, Maheva Maura, Nicolas Bridiau, Jean-Marie Piot, Thierry Maugard, Ingrid Fruitier-Arnaudin

Mar Drugs. 2019 Feb 27;17(3):140.

PMID: 30818840

λ-Carrageenan Suppresses Tomato Chlorotic Dwarf Viroid (TCDVd) Replication and Symptom Expression in Tomatoes

Jatinder S Sangha, Saveetha Kandasamy, Wajahatullah Khan, Navratan Singh Bahia, Rudra P Singh, Alan T Critchley, Balakrishnan Prithiviraj

Mar Drugs. 2015 May 8;13(5):2875-89.

PMID: 26006710

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Case Study

Preparation of λ-Carrageenan Nanogel Beads Bound with Iron Ions

Shu, Meng, et al. International journal of biological macromolecules 120 (2018): 2523-2529.

Iron-deficiency anemia (IDA) is a major global public health problem, and the iron fortifiers in diet are clearly needed in the prevention and improvement of IDA for humans. A novel nano-scaled gel beads of λ-carrageenan (λ-car) specifically binding with ferric ions was developed to be a promising iron fortifier with no adverse organoleptic changes on food.
Preparation of the λ-car-Fe³⁺ complex: A suitable amount of λ-car powder is dispersed in Millipore water to prepare a λ-car stock solution (2.0%, w/w). The dispersion is dissolved at 85 °C for 1 hour with continuous magnetic stirring. Ferric chloride solution (200 mM) is either mixed directly or added dropwise into the λ-car stock solution while stirring at 800 rpm, to achieve a final λ-car concentration of 1.0% (w/w) and ferric chloride concentration of 10 mM. The entire gel (from direct mixing) and small gel beads (from dropwise addition, stirring) are maintained at pH 2.3 with 2 M HCl to minimize the hydrolysis of iron ions in the λ-car. After equilibrating overnight, the samples are collected by centrifugation at 1000g and washed three times with Millipore water. Finally, the λ-car-Fe³⁺ complex is obtained by freeze-drying the samples.

Carrageenan Coating Derived from Red Algae for Marine Antifouling Applications

Kim, Dahee, and Sung Min Kang. Biomacromolecules 21.12 (2020): 5086-5092.

To inhibit marine biofouling, functional material surface coatings with antifouling/anti-biofouling properties have been extensively studied. Since carrageenan (CAR) is hydrophilic and negatively charged, we hypothesized that it could form a strong hydration layer when adsorbed onto solid surfaces, thereby exhibiting marine antifouling properties.
Here, we report a simple method for manufacturing marine antifouling coatings by crosslinking CAR with Zr(IV) ions. This method allows the direct grafting of CAR multilayers onto metal-polyphenol network (MPN) coated substrates. MPN/CAR coatings with various types and thicknesses of CAR were successfully prepared, and their marine antifouling performance was systematically investigated. Among the synthesized coatings, the MPN/λ-CAR coating demonstrated excellent capability to inhibit marine biofouling.