Caspase-8 Inhibitor I, Cell-Permeable

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For Research Use Only | Not For Clinical Use

CAT	IAR42415431
Molecular Weight	2000.42

Description	The Caspase 8 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-8. This small molecule/inhibitor is primarily used for Cancer applications.
Solubility	DMSO: 5 mg/mL
Assay	≥95% (HPLC)
Color	white
Form	lyophilized solid
Size	1MG
Storage Conditions	-20C

Activation of caspase-8 in Drug-Induced Apoptosis of B-lymphoid Cells Is Independent of CD95/Fas Receptor-Ligand Interaction and Occurs Downstream of caspase-3

T Wieder, F Essmann, A Prokop, K Schmelz, K Schulze-Osthoff, R Beyaert, B Dörken, P T Daniel

Blood. 2001 Mar 1;97(5):1378-87.

PMID: 11222383

Activation of caspase-9, but Not caspase-2 or caspase-8, Is Essential for Heat-Induced Apoptosis in Jurkat Cells

Shary N Shelton, Cindy D Dillard, John D Robertson

J Biol Chem. 2010 Dec 24;285(52):40525-33.

PMID: 20978129

Inhibition of CBLB Protects From Lethal Candida Albicans Sepsis

Gerald Wirnsberger, Florian Zwolanek, Tomoko Asaoka, Ivona Kozieradzki, Luigi Tortola, Reiner A Wimmer, Anoop Kavirayani, Friedrich Fresser, Gottfried Baier, Wallace Y Langdon, Fumiyo Ikeda, Karl Kuchler, etc.

Nat Med. 2016 Aug;22(8):915-23.

PMID: 27428901

P2X(7) Nucleotide Receptors Mediate caspase-8/9/3-dependent Apoptosis in Rat Primary Cortical Neurons

Qiongman Kong, Min Wang, Zhongji Liao, Jean M Camden, Sue Yu, Agnes Simonyi, Grace Y Sun, Fernando A Gonzalez, Laurie Erb, Cheikh I Seye, Gary A Weisman

Purinergic Signal. 2005 Dec;1(4):337-47.

PMID: 18404518

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