CAS 18829-70-4 (−)-Catechin - Analytical Products / Alfa Chemistry

CAT	AP18829704
CAS	18829-70-4
Structure
MDL Number	MFCD00135997
Molecular Weight	290.27
EC Number	242-611-7
InChI Key	PFTAWBLQPZVEMU-HIFRSBDPSA-N

Comparative Studies on the Hypolipidemic, Antioxidant and Hepatoprotective Activities of Catechin-Enriched Green and Oolong Tea in a Double-Blind Clinical Trial

Kamesh Venkatakrishnan, Hui-Fang Chiu, Ju-Chun Cheng, Ya-Hui Chang, Yan-Ying Lu, Yi-Chun Han, You-Cheng Shen, Kun-Shun Tsai, Chin-Kun Wang

Food Funct. 2018 Feb 21;9(2):1205-1213.

PMID: 29384173

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CAT	Size	Description	Price
AP18829704-1	10MG		Inquiry
AP18829704-2	5MG	≥97% (HPLC), from green tea	Inquiry

Case Study

Catechin Used for the Preparation of BSA-Pullulan Nanoparticles to Enhance Oxidative Stability of Pickering Emulsions

Liang, Bin, et al. LWT 208 (2024): 116728.

Catechin, a naturally occurring polyphenolic antioxidant, has demonstrated promising applications in stabilizing oil-in-water (O/W) emulsions. In a recent study, catechin was successfully incorporated into bovine serum albumin (BSA)-pullulan (PUL) nanoparticles (BPNs) to fabricate catechin-loaded BSA-PUL nanoparticles (BPCNs) via a pH-controlled self-assembly method. The resulting hybrid nanoparticles were designed to address the challenges of lipid oxidation in food emulsions, which limits shelf life and product quality.
Fourier transform infrared (FTIR) spectroscopy confirmed that catechin interacts non-covalently with BSA and PUL, forming stable nanoparticulate structures. Particle size analysis and zeta-potential measurements revealed that catechin plays a dual role: enhancing nanoparticle interfacial properties and promoting cross-linking among BSA molecules, which leads to larger and more stable structures. The radical scavenging capacity of catechin further contributed to improved antioxidant performance.
When used in Pickering emulsion systems, BPCNs exhibited significantly improved oxidative and storage stability compared to BPNs without catechin. This enhancement is attributed not only to catechin's inherent radical scavenging ability but also to its influence on nanoparticle surface charge and protein distribution.
This case highlights catechin's functional role in nanoparticle engineering for emulsion stabilization and demonstrates its potential as a bioactive additive in advanced food-grade emulsifiers. Such multifunctional nanoparticle systems represent a sustainable and effective approach to food preservation.

Catechin Used for the Synthesis of Arabinoxylan-Catechin Conjugates via Cold Plasma and Ultrasonic Treatments

Atehli, Dima, et al. Food Chemistry 472 (2025): 142986.

Catechin was employed to prepare arabinoxylan-catechin (AX-CA) conjugates through two green synthesis routes-cold plasma and ultrasonic treatment-highlighting its utility in modifying polysaccharides for enhanced functionality. The aqueous catechin solution (0.5 mg/mL) was mixed with an arabinoxylan solution at varying AX-to-catechin mass ratios (3:1, 2:1, 1.5:1) to form complexes with low (PM-L), medium (PM-M), and high (PM-H) grafting densities. The mixtures were stirred continuously at 300-400 rpm for 6 hours at 60 °C to ensure sufficient interaction.
Subsequent ethanol precipitation (2:1 ethanol to sample volume) was carried out at 4 °C for 2 hours. The precipitates were centrifuged (4000 g, 10 min), washed twice with ethanol (1:10 solid-to-liquid ratio) to remove unbound catechin, and then redissolved in distilled water (1:20 ratio). Dialysis was performed using a 3500 Da molecular weight cutoff membrane for 48 hours, with water replacement every 6 hours. The samples were finally freeze-dried and ground to obtain AX-CA conjugate powders.
Application of cold plasma (50 V, 3 min) and ultrasound (200 W, 3 min) enhanced catechin grafting onto arabinoxylan, as confirmed by UV-vis, FT-IR, and SEM analyses. These treatments offer chemical-free, sustainable alternatives for catechin-mediated functionalization of polysaccharides.

Catechin Used for the Synthesis of CA/CD@PLGA Nanospheres with Antimicrobial and Antibiofilm Activity

Zheng, Qinghua, Jianfeng Li, and Lijuan Yang. Microbial Pathogenesis 205 (2025): 107524.

Catechin, a natural flavonoid, was utilized for the synthesis of PLGA-coated catechin/cyclodextrin nanospheres (CA/CD@PLGA), aiming to combat pediatric pneumonia pathogens such as Streptococcus pneumoniae and MRSA. In this study, catechin (50 mg) and cyclodextrin (50 mg) were dissolved in 20 mL of ethanol and magnetically stirred at 40 °C. Separately, 50 mg of PLGA was dispersed in 10 mL of 2% acetic acid and stirred for 12 h to form a homogeneous polymer solution. The PLGA solution was then gradually introduced into the catechin/cyclodextrin mixture using a syringe while stirring vigorously for 60 min. The formation of a milky colloid signified the successful assembly of CA/CD@PLGA nanospheres, after which stirring continued for another 30 min. The colloid was collected via centrifugation (10000 rpm, 15 min), followed by washing with ethanol and deionized water, and dried at 60 °C for 6 h.
The resulting CA/CD@PLGA nanospheres demonstrated strong antibacterial efficacy (MIC: 128-130 μg/mL) and achieved an 83% reduction in biofilm formation. Mechanistically, the antibacterial effect was attributed to ROS-mediated cytotoxicity. Additionally, antifungal tests showed inhibition of protein synthesis in A. fumigatus and C. albicans. Cytotoxicity evaluation confirmed high biocompatibility (93% fibroblast cell viability), highlighting the therapeutic potential of catechin-loaded nanospheres in pediatric pneumonia treatment.