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CB-DMB

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For Research Use Only | Not For Clinical Use
CATIAR4242659
MDL NumberMFCD17215951
Molecular Weight472.37
InChI KeyMGLQFHOCPGELNL-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL
Assay≥98% (HPLC)
Formsolid
Size5MG, 25MG
Storage Conditions2-8°C
1

Blockade of the forward Na + /Ca 2+ exchanger suppresses the growth of glioblastoma cells through Ca 2+ -mediated cell death

Hui-Jie Hu, Shan-Shan Wang, Yan-Xia Wang, Yan Liu, Xue-Mei Feng, Ying Shen, Liang Zhu, Hong-Zhuan Chen, Mingke Song

Br J Pharmacol. 2019 Aug;176(15):2691-2707.

PMID: 31034096

1

Evidence for a Protective Role Played by the Na+/Ca2+ Exchanger in Cerebral Ischemia Induced by Middle Cerebral Artery Occlusion in Male Rats

Giuseppe Pignataro, Anna Tortiglione, Antonella Scorziello, Lucia Giaccio, Agnese Secondo, Beatrice Severino, Vincenzo Santagada, Giuseppe Caliendo, Salvatore Amoroso, Gianfranco Di Renzo, Lucio Annunziato

Neuropharmacology. 2004 Mar;46(3):439-48.

PMID: 14975699

1

Human Macrophages and Monocytes Express Functional Na(+)/Ca (2+) Exchangers 1 and 3

Rosaria I Staiano, Francescopaolo Granata, Agnese Secondo, Angelica Petraroli, Stefania Loffredo, Lucio Annunziato, Massimo Triggiani, Gianni Marone

Adv Exp Med Biol. 2013;961:317-26.

PMID: 23224891

1

Molecular Pharmacology of the Amiloride Analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a Pan Inhibitor of the Na+-Ca2+ Exchanger Isoforms NCX1, NCX2, and NCX3 in Stably Transfected Cells

Agnese Secondo, Anna Pannaccione, Pasquale Molinaro, Paolo Ambrosino, Pellegrino Lippiello, Alba Esposito, Maria Cantile, Priti R Khatri, Daniela Melisi, Gianfranco Di Renzo, Lucio Annunziato

J Pharmacol Exp Ther. 2009 Oct;331(1):212-21.

PMID: 19602550

1

Na+/Ca2+ Exchanger Maintains Ionic Homeostasis in the Peri-Infarct Area

Anna Tortiglione, Barbara Picconi, Ilaria Barone, Diego Centonze, Silvia Rossi, Cinzia Costa, Massimiliano Di Filippo, Alessandro Tozzi, Michela Tantucci, Giorgio Bernardi, Lucio Annunziato, Paolo Calabresi

Stroke. 2007 May;38(5):1614-20.

PMID: 17395860

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