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CCG-203971

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For Research Use Only | Not For Clinical Use
CATAP1443437748
CAS1443437-74-8
MDL NumberMFCD28166491
Molecular Weight408.88
InChI KeyHERLZBNILRVHQN-UHFFFAOYSA-N
Description≥98% (HPLC)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Conditionally Immortalized Gli1-positive Kidney Mesenchymal Cell Line Models Myofibroblast Transition

Eoghainín Ó hAinmhire, Haojia Wu, Yoshiharu Muto, Erinn L Donnelly, Flavia G Machado, Lucy X Fan, Monica Chang-Panesso, Benjamin D Humphreys

Am J Physiol Renal Physiol. 2019 Jan 1;316(1):F63-F75.

PMID: 30303712

1

Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds

Erika M Lisabeth, Dylan Kahl, Indiwari Gopallawa, Sarah E Haynes, Sean A Misek, Phillip L Campbell, Thomas S Dexheimer, Dinesh Khanna, David A Fox, Xiangshu Jin, Brent R Martin, Scott D Larsen, Richard R Neubig

ACS Pharmacol Transl Sci. 2019 Apr 12;2(2):92-100.

PMID: 32039344

1

Inhibition of Myocardin-Related Transcription factor/serum Response Factor Signaling Decreases Lung Fibrosis and Promotes Mesenchymal Cell Apoptosis

Thomas H Sisson, Iyabode O Ajayi, Natalya Subbotina, Amos E Dodi, Eva S Rodansky, Lauren N Chibucos, Kevin K Kim, Venkateshwar G Keshamouni, Eric S White, Yong Zhou, Peter D R Higgins, Scott D Larsen, Richard R Neubig, etc.

Am J Pathol. 2015 Apr;185(4):969-86.

PMID: 25681733

1

Local Delivery of Novel MRTF/SRF Inhibitors Prevents Scar Tissue Formation in a Preclinical Model of Fibrosis

Cynthia Yu-Wai-Man, Bradley Spencer-Dene, Richard M H Lee, Kim Hutchings, Erika M Lisabeth, Richard Treisman, Maryse Bailly, Scott D Larsen, Richard R Neubig, Peng T Khaw

Sci Rep. 2017 Mar 31;7(1):518.

PMID: 28364121

1

Pharmacokinetic Optimitzation of CCG-203971: Novel Inhibitors of the Rho/MRTF/SRF Transcriptional Pathway as Potential Antifibrotic Therapeutics for Systemic Scleroderma

Kim M Hutchings, Erika M Lisabeth, Walajapet Rajeswaran, Michael W Wilson, Roderick J Sorenson, Phillip L Campbell, Jeffrey H Ruth, Asif Amin, Pei-Suen Tsou, Jeffrey R Leipprandt, Samuel R Olson, Bo Wen, etc.

Bioorg Med Chem Lett. 2017 Apr 15;27(8):1744-1749.

PMID: 28285914

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