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CCT137690

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For Research Use Only | Not For Clinical Use
CATAP1095382050
CAS1095382-05-0
MDL NumberMFCD18206879
Molecular Weight551.48
InChI KeyGFLQCBTXTRCREJ-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Gene Mutations and Molecularly Targeted Therapies in Acute Myeloid Leukemia

Eleftheria Hatzimichael, Georgios Georgiou, Leonidas Benetatos, Evangelos Briasoulis

Am J Blood Res. 2013;3(1):29-51.

PMID: 23358589

1

Identification and Evaluation of Novel Drug Combinations of Aurora Kinase Inhibitor CCT137690 for Enhanced Efficacy in Oral Cancer Cells

Muhammad Furqan, Zille Huma, Zainab Ashfaq, Apsra Nasir, Rahim Ullah, Aishah Bilal, Maheen Iqbal, Muhammad Hashaam Khalid, Irshad Hussain, Amir Faisal

Cell Cycle. 2019 Sep;18(18):2281-2292.

PMID: 31318643

1

Inhibition of Aurora B by CCT137690 Sensitizes Colorectal Cells to Radiotherapy

Xiaoyu Wu, Wentao Liu, Qinhong Cao, Che Chen, Zhiwei Chen, Zhe Xu, Weisu Li, Fukun Liu, Xuequan Yao

J Exp Clin Cancer Res. 2014 Jan 29;33(1):13.

PMID: 24476310

1

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

Yangchun Xie, Shan Zhu, Meizuo Zhong, Manhua Yang, Xiaofan Sun, Jinbao Liu, Guido Kroemer, Michael Lotze, Herbert J Zeh 3rd, Rui Kang, Daolin Tang

Gastroenterology. 2017 Nov;153(5):1429-1443.e5.

PMID: 28764929

1

The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-amplified Neuroblastoma in Vivo

Amir Faisal, Lynsey Vaughan, Vassilios Bavetsias, Chongbo Sun, Butrus Atrash, Sian Avery, Yann Jamin, Simon P Robinson, Paul Workman, Julian Blagg, Florence I Raynaud, Suzanne A Eccles, Louis Chesler, Spiros Linardopoulos

Mol Cancer Ther. 2011 Nov;10(11):2115-23.

PMID: 21885865

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