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CD437

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For Research Use Only | Not For Clinical Use
CATAP125316601
CAS125316-60-1
Structure
MDL NumberMFCD03106506
Molecular Weight398.49
InChI KeyLDGIHZJOIQSHPB-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: >10 mg/mL; H2O: insoluble
Assay≥98% (HPLC)
Coloryellow
Formsolid
Impurity Content~0.5 mol/mol water
MP271.6-276 °C
Size5MG, 25MG
Storage Conditions−20°C
1

A New Class of Synthetic Retinoid Antibiotics Effective Against Bacterial Persisters

Wooseong Kim, Wenpeng Zhu, Gabriel Lambert Hendricks, Daria Van Tyne, Andrew D Steele, Colleen E Keohane, Nico Fricke, Annie L Conery, Steven Shen, Wen Pan, Kiho Lee, Rajmohan Rajamuthiah, Beth Burgwyn Fuchs, etc.

Nature. 2018 Apr 5;556(7699):103-107.

PMID: 29590091

1

Bactericidal and Anti-biofilm Activity of the Retinoid Compound CD437 Against

Fang Tan, Pengfei She, Linying Zhou, Yiqing Liu, Lihua Chen, Zhen Luo, Yong Wu

Front Microbiol. 2019 Oct 9;10:2301.

PMID: 31649642

1

DNA Polymerase Alpha Is Essential for Intracellular Amplification of Hepatitis B Virus Covalently Closed Circular DNA

Liudi Tang, Muhammad Sheraz, Michael McGrane, Jinhong Chang, Ju-Tao Guo

PLoS Pathog. 2019 Apr 26;15(4):e1007742.

PMID: 31026293

1

Structure-based Design of Trifarotene (CD5789), a Potent and Selective RARγ Agonist for the Treatment of Acne

Etienne Thoreau, Jean-Marie Arlabosse, Claire Bouix-Peter, Sandrine Chambon, Laurent Chantalat, Sébastien Daver, Laurence Dumais, Gwenaëlle Duvert, Angélique Feret, Gilles Ouvry, Jonathan Pascau, Catherine Raffin, etc.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1736-1741.

PMID: 29706423

1

The Antitumor Toxin CD437 Is a Direct Inhibitor of DNA Polymerase α

Ting Han, Maria Goralski, Emanuela Capota, Shae B Padrick, Jiwoong Kim, Yang Xie, Deepak Nijhawan

Nat Chem Biol. 2016 Jul;12(7):511-5.

PMID: 27182663

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