CAS 75450-34-9 CGP-37157 - Analytical Products / Alfa Chemistry

CAT	AP75450349-A
CAS	75450-34-9
Structure
MDL Number	MFCD09055422
Molecular Weight	324.22
InChI Key	KQEPIRKXSUIUTH-UHFFFAOYSA-N

Description	≥98% (HPLC), powder
Solubility	DMSO: ≥20 mg/mL
Assay	≥98% (HPLC)
Color	white
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

CGP-37157 Inhibits the Sarcoplasmic Reticulum Ca²+ ATPase and Activates Ryanodine Receptor Channels in Striated Muscle

Jake T Neumann, Paula L Diaz-Sylvester, Sidney Fleischer, Julio A Copello

Mol Pharmacol. 2011 Jan;79(1):141-7.

PMID: 20923851

1

Inhibition of L-type Ca2+ Channel by Mitochondrial Na+-Ca2+ Exchange Inhibitor CGP-37157 in Rat Atrial Myocytes

Le Thi Thu, Joung Real Ahn, Sun-Hee Woo

Eur J Pharmacol. 2006 Dec 15;552(1-3):15-9.

PMID: 17054940

1

Pharmacological Investigation of Mitochondrial ca(2+) Transport in Central Neurons: Studies With CGP-37157, an Inhibitor of the Mitochondrial Na(+)-Ca(2+) Exchanger

J M Scanlon, J B Brocard, A K Stout, I J Reynolds

Cell Calcium. Nov-Dec 2000;28(5-6):317-27.

PMID: 11115371

1

Pharmacological Modulation of Mitochondrial Ca 2+ Content Regulates Sarcoplasmic Reticulum Ca 2+ Release via Oxidation of the Ryanodine Receptor by Mitochondria-Derived Reactive Oxygen Species

Shanna Hamilton, Radmila Terentyeva, Tae Yun Kim, Peter Bronk, Richard T Clements, Jin O-Uchi, György Csordás, Bum-Rak Choi, Dmitry Terentyev

Front Physiol. 2018 Dec 21;9:1831.

PMID: 30622478

1

Voltage-gated Ca(2+) Influx and Insulin Secretion in Human and Mouse Beta-Cells Are Impaired by the Mitochondrial Na(+)/Ca(2+) Exchange Inhibitor CGP-37157

Dan S Luciani, Peter Ao, Xiaoke Hu, Garth L Warnock, James D Johnson

Eur J Pharmacol. 2007 Dec 8;576(1-3):18-25.

PMID: 17719029

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