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CLP257

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For Research Use Only | Not For Clinical Use
CATAP1181081719
CAS1181081-71-9
MDL NumberMFCD28166488
Molecular Weight307.34
InChI KeySKCADXVKQRCWTR-GHXNOFRVSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Color, white to yellow to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Chloride Extrusion Enhancers as Novel Therapeutics for Neurological Diseases

Martin Gagnon, Marc J Bergeron, Guillaume Lavertu, Annie Castonguay, Sasmita Tripathy, Robert P Bonin, Jimena Perez-Sanchez, Dominic Boudreau, Bin Wang, Lionel Dumas, Isabelle Valade, Karine Bachand, Mariève Jacob-Wagner, etc.

Nat Med. 2013 Nov;19(11):1524-8.

PMID: 24097188

1

KCC2 Function Modulates in Vitro Ictogenesis

Shabnam Hamidi, Massimo Avoli

Neurobiol Dis. 2015 Jul;79:51-8.

PMID: 25926348

1

Reply to The small molecule CLP257 does not modify activity of the K +-Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

Martin Gagnon, Marc J Bergeron, Jimena Perez-Sanchez, Isabel Plasencia-Fernández, Louis-Etienne Lorenzo, Antoine G Godin, Annie Castonguay, Robert P Bonin, Yves De Koninck

Nat Med. 2017 Dec 7;23(12):1396-1398.

PMID: 29216044

1

The small molecule CLP257 does not modify activity of the K +-Cl - co-transporter KCC2 but does potentiate GABA A receptor activity

Ross A Cardarelli, Karen Jones, Lucie I Pisella, Heike J Wobst, Lisa J McWilliams, Paul M Sharpe, Matthew P Burnham, David J Baker, Ilona Chudotvorova, Justine Guyot, Liliya Silayeva, Danielle H Morrow, etc.

Nat Med. 2017 Dec 7;23(12):1394-1396.

PMID: 29216042

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