CAS 8001-29-4 Cottonseed oil - Analytical Products / Alfa Chemistry

CAT	AP8001294
CAS	8001-29-4
MDL Number	MFCD00130872

Description	United States Pharmacopeia (USP) Reference Standard
Size	1G

A 5-day High-Fat Diet Rich in Cottonseed Oil Improves Cholesterol Profiles and Triglycerides Compared to Olive Oil in Healthy Men

Kristine R Polley, Natalie J Oswell, Ronald B Pegg, Chad M Paton, Jamie A Cooper

Nutr Res. 2018 Dec;60:43-53.

PMID: 30527259

Cottonseed Oil in Diets for Broilers in the Pre-Starter and Starter Phases

Vânia Batista de Sousa Lima, Leilane Rocha Barros Dourado, Luciana Pereira Machado, Daniel Biagiotti, Stélio Bezerra Pinheiro de Lima, Guilherme José Bolzani de Campos Ferreira, Leonardo Atta Farias, Francinete Alves de Sousa, etc.

PLoS One. 2016 Jan 25;11(1):e0147695.

PMID: 26807917

Cottonseed Oil Protects Against Intestinal Inflammation in Dextran Sodium Sulfate-Induced Inflammatory Bowel Disease

Jin-Sil Park, JeongWon Choi, Sun-Hee Hwang, Jae-Kyung Kim, Eun-Kyung Kim, Seon-Young Lee, Bo-In Lee, Sung-Hwan Park, Mi-La Cho

J Med Food. 2019 Jul;22(7):672-679.

PMID: 31112045

Metabolic Engineering of Cottonseed Oil Biosynthesis Pathway via RNA Interference

Zhongping Xu, Jingwen Li, Xiaoping Guo, Shuangxia Jin, Xianlong Zhang

Sci Rep. 2016 Sep 13;6:33342.

PMID: 27620452

Solubilizing Excipients in Oral and Injectable Formulations

Robert G Strickley

Pharm Res. 2004 Feb;21(2):201-30.

PMID: 15032302

* Products or Services Interested: Cottonseed oil (8001-29-4)
* Your question
* Name
* Email
Verification Code

Case Study

Cottonseed Oil Used for the Synthesis of Acrylated-Epoxidized Resins in Bio-Based UV-Curable Coatings

Vonsul, Marta-Ievheniia, and Dean C. Webster. Progress in Organic Coatings 185 (2023): 107883.

Cottonseed oil, a renewable and underutilized plant oil, has been successfully employed in the synthesis of bio-based UV-curable polymer resins, offering a sustainable alternative to petroleum-derived materials. This study highlights the preparation and application of acrylated-epoxidized cottonseed oil (AECO) as the primary resin in photopolymerizable formulations.
The process began with the epoxidation of cottonseed oil using in situ generated peracetic acid, followed by acrylation with acrylic acid. The acrylated product (AECO) was used as a crosslinkable monomer in UV-curable systems. The formulation was optimized by incorporating reactive diluents such as 1,6-hexanediol diacrylate and trimethylolpropane triacrylate to tailor mechanical and thermal performance.
Compared with conventional petroleum-based resins, AECO-based materials demonstrated superior flexibility while maintaining desirable mechanical integrity, making them particularly attractive for applications on wood substrates, paper, and printed electronics. Thermal analysis and mechanical testing confirmed the viability of AECO resins under industrial conditions.
Importantly, this study also benchmarked AECO formulations against commercial products, revealing competitive performance and underscoring the value of cottonseed oil as a green feedstock. The dual advantage of utilizing an abundant agricultural by-product and implementing UV curing technology supports the broader transition toward sustainable material development.
Overall, cottonseed oil proves to be a versatile and eco-friendly raw material for the synthesis of advanced, bio-based UV-curable resins suitable for a variety of high-performance industrial coatings.

Cottonseed Oil Used for the Synthesis of Amine-Terminated Prepolymers in Toughened Epoxy Resin Applications

Narute, Prashant, et al. Progress in Organic Coatings 88 (2015): 316-324.

Cottonseed oil (CSO) has been effectively utilized for the synthesis of polymerizable epoxides and amine-terminated prepolymers aimed at enhancing the performance of epoxy resin systems. Through Prilezhaev epoxidation, CSO was converted to epoxidized cottonseed oil (ECSO) using formic acid and hydrogen peroxide, achieving an oxirane oxygen content of 5.01% and a product yield of 84.66%.
The ECSO was further reacted with triethylenetetramine (TETA) to synthesize prepolymers (PPECSO) with terminal amine groups. These prepolymers were blended with diglycidyl ether of bisphenol-A (DGEBA) in varying ratios (60:40, 50:50, 40:60) to produce modified epoxy resins. Upon curing, these hybrid systems formed highly crosslinked networks with improved toughness and flexibility.
Characterization of the modified epoxies revealed enhanced thermal stability, increased elongation, and greater resistance to solvents, water vapor transmission, and corrosion. The presence of ECSO also contributed to reduced brittleness, making the materials suitable for protective coatings and structural applications requiring impact resistance.
These findings demonstrate the dual role of cottonseed oil as a renewable feedstock and functional modifier in thermoset polymer design. The incorporation of ECSO-derived prepolymers into epoxy systems represents a promising route for producing high-performance, bio-based coatings with tunable mechanical and chemical resistance properties.

Cottonseed Oil Used for the Preparation of Beeswax-Based Bigel in Nanocellulose-Enhanced Ophthalmic Drug Delivery

Habibullah, Sk, et al. Journal of Drug Delivery Science and Technology (2025): 107287.

Cottonseed oil (CSO) has been utilized as a key component in the formulation of a novel beeswax-cottonseed oil-based oleogel for ophthalmic applications. When combined with nanocellulose hydrogel, the resulting bigel serves as a biocompatible platform for the controlled delivery of moxifloxacin HCl, a broad-spectrum antibiotic used in corneal infection treatment.
The bigel was fabricated via hot emulsification, where molten beeswax was dissolved in CSO at a 10:90 ratio to form the oleogel phase. This oleogel was then blended with nanocrystalline cellulose (NCC)-based hydrogel containing dissolved moxifloxacin to yield a hybrid bigel system. FTIR analysis revealed reduced hydrogen bonding with increasing oleogel content, while XRD and DSC studies confirmed the drug's amorphous dispersion within the matrix.
Mechanical characterization indicated improved cohesiveness and adhesiveness due to beeswax, while CSO contributed to the gel's viscoelastic fluidity. Notably, the formulation exhibited enhanced corneal permeation following an anomalous Fickian release model and showed strong antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa-surpassing the performance of hydrogel alone.
The beeswax-cottonseed oil bigel also demonstrated excellent corneal compatibility, making it a promising bio-based delivery vehicle. These results underscore cottonseed oil's role not only as a structural oleogelator but also as a sustainable and functional excipient in advanced ophthalmic drug delivery systems.