CAS 686347-12-6 CP-945,598 - Analytical Products / Alfa Chemistry

CAT	AP686347126
CAS	686347-12-6
Molecular Weight	546.88

Description	≥98% (HPLC)
Solubility	DMSO: 1 mg/mL, clear (warmed)
Assay	≥98% (HPLC)
Color	white to beige
Form	powder
Size	5MG, 25MG
Storage Conditions	room temp

1

Discovery of 1-[9-(4-chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

David A Griffith, John R Hadcock, Shawn C Black, Philip A Iredale, Philip A Carpino, Paul DaSilva-Jardine, Robert Day, Joseph DiBrino, Robert L Dow, Margaret S Landis, Rebecca E O'Connor, Dennis O Scott

J Med Chem. 2009 Jan 22;52(2):234-7.

PMID: 19102698

1

Efficacy and Safety of CP-945,598, a Selective Cannabinoid CB1 Receptor Antagonist, on Weight Loss and Maintenance

Louis J Aronne, Nick Finer, Priscilla A Hollander, Richard D England, Solomon S Klioze, Robert D Chew, Robert J Fountaine, Coralie M Powell, John D Obourn

Obesity (Silver Spring). 2011 Jul;19(7):1404-14.

PMID: 21293451

1

Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-chlorophenyl)-9-(4-chlorophenyl)-9H-purin-6-yl)-4-(ethylamino)piperidine-4-carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers

Zhuang Miao, Hao Sun, Jennifer Liras, Chandra Prakash

Drug Metab Dispos. 2012 Mar;40(3):568-78.

PMID: 22187487

1

Excretion, Metabolism, and Pharmacokinetics of CP-945,598, a Selective Cannabinoid Receptor Antagonist, in Rats, Mice, and Dogs

Zhuang Miao, Dennis O Scott, David A Griffith, Robert Day, Chandra Prakash

Drug Metab Dispos. 2011 Dec;39(12):2191-208.

PMID: 21875952

1

In Vitro and in Vivo Pharmacology of CP-945,598, a Potent and Selective Cannabinoid CB(1) Receptor Antagonist for the Management of Obesity

John R Hadcock, David A Griffith, Phillip A Iredale, Phillip A Carpino, Robert L Dow, Shawn C Black, Rebecca O'Connor, Denise Gautreau, Jeffrey S Lizano, Karen Ward, Diane M Hargrove, Dawn Kelly-Sullivan, etc.

Biochem Biophys Res Commun. 2010 Apr 2;394(2):366-71.

PMID: 20211605

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