CAS 693288-97-0 CPPHA - Analytical Products / Alfa Chemistry

CAT	AP693288970
CAS	693288-97-0
MDL Number	MFCD12912405
Molecular Weight	406.82
InChI Key	UFOUABRZSDGGAZ-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: >20 mg/mL
Assay	≥98% (HPLC)
Form	solid
Size	5MG, 25MG
Storage Conditions	−20°C

1

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

Julie A O'Brien, Wei Lemaire, Marion Wittmann, Marlene A Jacobson, Sookhee N Ha, David D Wisnoski, Craig W Lindsley, Hervé J Schaffhauser, Blake Rowe, Cyrille Sur, Mark E Duggan, Douglas J Pettibone, P Jeffrey Conn, etc.

J Pharmacol Exp Ther. 2004 May;309(2):568-77.

PMID: 14747613

1

Allosteric Potentiators of Metabotropic Glutamate Receptor Subtype 5 Have Differential Effects on Different Signaling Pathways in Cortical Astrocytes

Yongqin Zhang, Alice L Rodriguez, P Jeffrey Conn

J Pharmacol Exp Ther. 2005 Dec;315(3):1212-9.

PMID: 16135701

1

Development of Allosteric Modulators of GPCRs for Treatment of CNS Disorders

Hilary Highfield Nickols, P Jeffrey Conn

Neurobiol Dis. 2014 Jan;61:55-71.

PMID: 24076101

1

Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct From 2-Methyl-6-(phenylethynyl)-pyridine Binding

Mariusz Butkiewicz, Alice L Rodriguez, Shane E Rainey, Joshua Wieting, Vincent B Luscombe, Shaun R Stauffer, Craig W Lindsley, P Jeffrey Conn, Jens Meiler

ACS Chem Neurosci. 2019 Aug 21;10(8):3427-3436.

PMID: 31132237

1

N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts Through a Novel Site as a Positive Allosteric Modulator of Group 1 Metabotropic Glutamate Receptors

Yelin Chen, Cyril Goudet, Jean-Philippe Pin, P Jeffrey Conn

Mol Pharmacol. 2008 Mar;73(3):909-18.

PMID: 18056795

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