CAS 472-70-8 β-Cryptoxanthin - Analytical Products / Alfa Chemistry

CAT	AP472708
CAS	472-70-8
Structure
Molecular Weight	552.87
InChI Key	DMASLKHVQRHNES-FKKUPVFPSA-N

Description	≥97% (TLC)
Solubility	chloroform: 1 mg/mL
Assay	≥97% (TLC)
Color	faint red to very dark red
Form	powder
MP	169-170 °C
Size	1MG
Storage Conditions	−20°C

Absorption, Metabolism, and Functions of β-cryptoxanthin

Betty J Burri, Michael R La Frano, Chenghao Zhu

Nutr Rev. 2016 Feb;74(2):69-82.

PMID: 26747887

Anti-stress Effect of β-Cryptoxanthin in Satsuma Mandarin Orange on Females

Keiko Unno, Shigenori Noda, Hirohiko Nii, Yohei Kawasaki, Kazuaki Iguchi, Hiroshi Yamada

Biol Pharm Bull. 2019;42(8):1402-1408.

PMID: 31366875

β-Cryptoxanthin Induced Anti-Proliferation and Apoptosis by G0/G1 Arrest and AMPK Signal Inactivation in Gastric Cancer

Meili Gao, Fan Dang, Chun Deng

Eur J Pharmacol. 2019 Sep 15;859:172528.

PMID: 31288004

β-Cryptoxanthin Induces UCP-1 Expression via a RAR Pathway in Adipose Tissue

Hideyuki Hara, Haruya Takahashi, Shinsuke Mohri, Hiroki Murakami, Satoko Kawarasaki, Mari Iwase, Nobuyuki Takahashi, Minoru Sugiura, Tsuyoshi Goto, Teruo Kawada

J Agric Food Chem. 2019 Sep 25;67(38):10595-10603.

PMID: 31475817

β-Cryptoxanthin-Biofortified Hen Eggs Enhance Vitamin A Status When Fed to Male Mongolian Gerbils

Emily K Heying, Kaitlin Leary Ziemer, Jacob P Tanumihardjo, Natalia Palacios-Rojas, Sherry A Tanumihardjo

J Nutr. 2018 Aug 1;148(8):1236-1243.

PMID: 30137479

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Case Study

Potential Molecular Mechanisms of β-Cryptoxanthin in Preventing Cancer Development/Progression

Lim, J. Y., & Wang, X. D. (2020). Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1865(11), 158652.

To better understand the potential role of carotenoids in cancer chemoprevention, human studies are urgently needed to explore the mechanisms by which β-cryptoxanthin affects genetic and epigenetic signaling pathways.
β-Cryptoxanthin supplementation inhibits lung inflammation by reducing nuclear NF-κB and AP-1 levels and suppresses lung cancer progression by restoring the RARβ, SIRT1, and NAChRs/PI3K/Akt pathways in lung cancer mouse models. β-Cryptoxanthin treatment regulates p73 RNA splicing, leading to reduced production of the oncogenic truncated form ∆NP73, thereby inhibiting proliferation and helping to suppress colon cancer in mice. Additionally, β-cryptoxanthin increases the acetylation of p53 (the active form of p53), which inhibits HIF-1α and LDHA while increasing G6Pase and PEPCK, thus suppressing HCC in both WT and BCO1/BCO2 DKO mice. Moreover, β-cryptoxanthin upregulates p53, inducing G0/G1 cell cycle arrest and apoptosis in gastric and bladder cancer in mice.

Anti-Arthritic Effects of β-Cryptoxanthin on Cartilage Degradation

Imada, Keisuke, et al. Biochemical and biophysical research communications 476.4 (2016): 352-358.

Epidemiological studies have shown a negative correlation between the incidence of rheumatoid arthritis and daily intake of β-cryptoxanthin.
In this study, the effects of β-cryptoxanthin on extracellular matrix metabolism in cartilage were investigated both in vivo and in vitro. Oral administration of β-cryptoxanthin (0.1-1 mg/kg) to antigen-induced arthritis rats inhibited the loss of glycosaminoglycans in joint cartilage and interfered with aggrecan degradation mediated by aggrecanases. In cultured porcine articular cartilage explants, β-cryptoxanthin also inhibited interleukin 1α (IL-1α)-induced aggrecan degradation. β-Cryptoxanthin (1-10 μM) dose-dependently downregulated IL-1α-induced gene expression of aggrecanase 1 (ADAMTS-4) and aggrecanase 2 (ADAMTS-5) in cultured human chondrocytes. Furthermore, β-cryptoxanthin was found to enhance the gene expression of aggrecan core protein in chondrocytes. These findings provide new evidence for the anti-arthritic effects of β-cryptoxanthin and suggest that β-cryptoxanthin may help to prevent the progression of rheumatoid arthritis and osteoarthritis.