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CX516

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For Research Use Only | Not For Clinical Use
CATAP154235833
CAS154235-83-3
Structure
MDL NumberMFCD00943201
Molecular Weight241.29
InChI KeyANDGGVOPIJEHOF-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityH2O: 5 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Placebo-Controlled Add-On Trial of the Ampakine, CX516, for Cognitive Deficits in Schizophrenia

Donald C Goff, J Steven Lamberti, Andrew C Leon, Michael F Green, Alexander L Miller, Jayendra Patel, Theo Manschreck, Oliver Freudenreich, Steven A Johnson

Neuropsychopharmacology. 2008 Feb;33(3):465-72.

PMID: 17487227

1

Facilitative Effects of the Ampakine CX516 on Short-Term Memory in Rats: Correlations With Hippocampal Neuronal Activity

R E Hampson, G Rogers, G Lynch, S A Deadwyler

J Neurosci. 1998 Apr 1;18(7):2748-63.

PMID: 9502832

1

Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2-/y Mice

Luca Murru, Elena Vezzoli, Anna Longatti, Luisa Ponzoni, Andrea Falqui, Alessandra Folci, Edoardo Moretto, Veronica Bianchi, Daniela Braida, Mariaelvina Sala, Patrizia D'Adamo, Silvia Bassani, Maura Francolini, etc.

Cereb Cortex. 2017 Nov 1;27(11):5369-5384.

PMID: 28968657

1

Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity

Tetsuya Tatsukawa, Matthieu Raveau, Ikuo Ogiwara, Satoko Hattori, Hiroyuki Miyamoto, Emi Mazaki, Shigeyoshi Itohara, Tsuyoshi Miyakawa, Mauricio Montal, Kazuhiro Yamakawa

Mol Autism. 2019 Mar 28;10:15.

PMID: 30962870

1

Structural Analysis of the Positive AMPA Receptor Modulators CX516 and Me-CX516 in Complex With the GluA2 Ligand-Binding Domain

Christian Krintel, Kasper Harpsøe, Linda G Zachariassen, Dan Peters, Karla Frydenvang, Darryl S Pickering, Michael Gajhede, Jette S Kastrup

Acta Crystallogr D Biol Crystallogr. 2013 Sep;69(Pt 9):1645-52.

PMID: 23999288

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