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CYP3cide

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For Research Use Only | Not For Clinical Use
CATIAR4242852
MDL NumberMFCD22417344
Molecular Weight456.59
InChI KeyWDWIMDKOXZZYHH-FQEVSTJZSA-N
Description≥98% (HPLC)
SolubilityDMSO: >10 mg/mL (warmed)
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditionsroom temp
1

Allosteric Activation of Midazolam CYP3A5 Hydroxylase Activity by Icotinib - Enhancement by Ketoconazole

XiaoMei Zhuang, TianHong Zhang, SiJia Yue, Juan Wang, Huan Luo, YunXia Zhang, Zheng Li, JinJing Che, HaiYing Yang, Hua Li, MingShe Zhu, Chuang Lu

Biochem Pharmacol. 2016 Dec 1;121:67-77.

PMID: 27666601

1

Biosynthesis and Identification of Metabolites of Maraviroc and Their Use in Experiments to Delineate the Relative Contributions of Cytochrome P4503A4 Versus 3A5

Elaine Tseng, Gwendolyn D Fate, Gregory S Walker, Theunis C Goosen, R Scott Obach

Drug Metab Dispos. 2018 May;46(5):493-502.

PMID: 29475834

1

In Vitro Kinetic Characterization of Axitinib Metabolism

Michael A Zientek, Theunis C Goosen, Elaine Tseng, Jian Lin, Jonathan N Bauman, Gregory S Walker, Ping Kang, Ying Jiang, Sascha Freiwald, David Neul, Bill J Smith

Drug Metab Dispos. 2016 Jan;44(1):102-14.

PMID: 26512042

1

Relative Contributions of Cytochrome CYP3A4 Versus CYP3A5 for CYP3A-cleared Drugs Assessed in Vitro Using a CYP3A4-selective Inactivator (CYP3cide)

Elaine Tseng, Robert L Walsky, Ricardo A Luzietti Jr, Jennifer J Harris, Rachel E Kosa, Theunis C Goosen, Michael A Zientek, R Scott Obach

Drug Metab Dispos. 2014 Jul;42(7):1163-73.

PMID: 24737844

1

Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an in Vitro Tool for Delineating the Relative Roles of CYP3A4 Versus CYP3A5 in the Metabolism of Drugs

Robert L Walsky, R Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Michael West, Kieran F Geoghegan, Christopher J Helal, Gregory S Walker, Theunis C Goosen, Michael A Zientek

Drug Metab Dispos. 2012 Sep;40(9):1686-97.

PMID: 22645092

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