CAS 50-99-7 D-Glucose (Dextrose) - Analytical Products / Alfa Chemistry

CAT	APS50997A
CAS	50-99-7
Structure
Synonyms	Tackidex 30L75,(+)-Glucose, Maxim Energy Gel, Sugar, grape, SB-266486, Dextropur, Dextrose, Goldsugar, CPC hydrate, Clearsweet 95, Tabfine 097(HS), Meritose 200, D(+)-Glucose, Staleydex 111, TDA-S, Cerelose 2001, Glucose, Cerelose, Corn sugar, Glucosoft, Hi-Mesh, NSC 287045, Glucolin, Grape sugar, Dextrosol, Glucodin, Anhydrous dextrose, Glucopyranose, Toleran G, Vadex, Cartose, C*Dry GL 01934, Glucosteril, Staleydex 130, Staleydex 333, Meritose, D 50W, Staleydex 95M, Clintose L, FeedBead, Roclys C 30725, Brake (pH-encapsulated glucose), Roferose ST, TDA-C
IUPAC Name	(2RS,3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydropyran-2,3,4,5-tetrol
Molecular Weight	180.16
Molecular Formula	C6H12O6
InChI	InChI=1S/C6H12O6/c7-1-3(9)5(11)6(12)4(10)2-8/h1,3-6,8-12H,2H2/t3-,4+,5+,6+/m0/s1

Accurate Mass	180.0634
Shipping	Room Temperature
Storage Conditions	Room Temperature
Subcategory	National Institute of Science and Technology (NIST), Biosynthetic compounds

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Case Study

Dextrose Used for the In-Situ Synthesis of BiVO₄/Carbon Nanocomposites

Padwal, Yogita, et al. International Journal of Hydrogen Energy 106 (2025): 511-527.

Dextrose serves as a critical carbon source in the in-situ synthesis of BiVO₄/Carbon (BiVO₄/C) nanocomposites, enabling the formation of multifunctional materials with enhanced properties. In this study, BiVO₄ was synthesized via a hydrothermal method involving the reaction of ammonium metavanadate and bismuth nitrate in an aqueous medium. To fabricate the BiVO₄/C composite, varying concentrations of dextrose (0.01, 0.02, and 0.03 M) were introduced directly into the precursor solution, acting as a sacrificial carbon precursor during the hydrothermal process at 180 °C for 12 hours.
The presence of dextrose promotes carbon deposition on the BiVO₄ surface, forming a uniform carbonaceous matrix throughout the nanocomposite. The carbon incorporation is expected to improve the electrical conductivity and surface reactivity of the material, making it suitable for energy, photocatalytic, or environmental applications.
The samples obtained, labeled BVC-1, BVC-2, and BVC-3 according to dextrose concentration, were subjected to extensive characterization for property optimization. This synthesis route highlights the effectiveness of dextrose as a green, low-cost, and easily available carbon source for engineering nanostructured materials with improved physicochemical properties. Thus, dextrose plays a pivotal role in tailoring the functionality of BiVO₄ composites for advanced material applications.

Dextrose Used for the Preparation of Alginate/Dextrose Gel Beads as a Carrier for Protease Immobilization

Abdella, Mohamed AA, Samia A. Ahmed, and Mohamed E. Hassan. International Journal of Biological Macromolecules 230 (2023): 123139.

Dextrose plays a crucial role in the preparation of hybrid gel beads used for enzyme immobilization, as demonstrated in a study involving protease from Bacillus thuringiensis strain MA8. In this application, dextrose was blended with alginate in a 1:1 ratio (final concentration 2%) to form Alginate/Dextrose (Alg/dex) gel beads via ionic gelation in calcium chloride solution. The resulting beads served as a novel carrier for protease immobilization with a high yield of 77.6%.
Following gel formation, the beads were chemically activated using polyethyleneimine (PEI) and glutaraldehyde (GA) to introduce aldehyde groups for covalent attachment of the enzyme. Immobilization enhanced the protease's thermal stability, shifting the optimum temperature 10 °C higher and increasing the deactivation energy by 1.47-fold compared to the free enzyme. The immobilized protease also demonstrated lower activation energy and deactivation rate constants, with improved half-life and D-values, confirming the stabilizing effect of the Alg/dex matrix.
Kinetic analysis showed increased Km and Vmax values, while reusability studies revealed the enzyme retained 92.7% and 52.4% activity after 8 and 12 cycles, respectively. These findings highlight dextrose's functional role in forming a stable and reusable immobilization platform, making it a valuable component in biocatalyst support materials.

Dextrose Used for the Surface Modification of Gd₂O₃@Fe₃O₄ Nanocomposites for Biomedical Imaging Applications

Shabanzadeh-Kouyakhi, Alireza, Afshin Masoudi, and Mohammad Ardestani. Ceramics International 46.9 (2020): 13442-13448.

Dextrose plays a vital role in stabilizing Gd₂O₃@Fe₃O₄ nanocomposites for biomedical use, particularly in magnetic resonance imaging (MRI) contrast enhancement. In this study, dextrose was used as a biocompatible capping agent to improve colloidal stability of gadolinium oxide-coated iron oxide nanoparticles synthesized via a multi-step aqueous route.
Initially, iron oxide nanoparticles were synthesized by coprecipitating FeCl₂·4H₂O and FeCl₃·6H₂O at two different temperatures (25 °C and 80 °C), yielding Fe₃O₄ crystallites of varying sizes. These particles served as nucleation seeds for the heterogeneous growth of Gd₂O₃, which was formed by reacting GdCl₃·6H₂O in alkaline conditions, followed by annealing at 300 °C to improve crystallinity.
Subsequently, a 1:1 (w/w) solution of dextrose and Gd₂O₃@Fe₃O₄ nanoparticles was prepared at 80 °C and stirred to facilitate surface adsorption. After cooling, overnight stirring enabled uniform dextrose capping, yielding a stable colloidal suspension. Characterization by XRD, TEM, FTIR, and DLS confirmed successful dextrose coating, with hydrodynamic diameters of 208-247 nm. MTT assay results showed high biocompatibility, with 80% cell viability at 285 μg/mL nanoparticle concentration.
This study confirms that dextrose is a facile, non-toxic capping agent ideal for biomedical nanoparticle functionalization, enhancing stability, biocompatibility, and dispersibility in aqueous media-key attributes for MRI contrast agents.