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Desmosterol

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For Research Use Only | Not For Clinical Use
CATAP313042
CAS313-04-2
Structure
MDL NumberMFCD00056432
Molecular Weight384.64
EC Number206-236-2
InChI KeyAVSXSVCZWQODGV-DPAQBDIFSA-N
Description≥84% (GC)
Assay≥84% (GC)
Size5MG, 10MG
Storage Conditions−20°C
1

Cell-specific Discrimination of Desmosterol and Desmosterol Mimetics Confers Selective Regulation of LXR and SREBP in Macrophages

Evan D Muse, Shan Yu, Chantle R Edillor, Jenhan Tao, Nathanael J Spann, Ty D Troutman, Jason S Seidman, Adam Henke, Jason T Roland, Katherine A Ozeki, Bonne M Thompson, Jeffrey G McDonald, John Bahadorani, etc.

Proc Natl Acad Sci U S A. 2018 May 15;115(20):E4680-E4689.

PMID: 29632203

1

CYP46A1, the Rate-Limiting Enzyme for Cholesterol Degradation, Is Neuroprotective in Huntington's Disease

Lydie Boussicault, Sandro Alves, Antonin Lamazière, Anabelle Planques, Nicolas Heck, Lara Moumné, Gaëtan Despres, Susanne Bolte, Amélie Hu, Christiane Pagès, Laurie Galvan, Francoise Piguet, Patrick Aubourg, etc.

Brain. 2016 Mar;139(Pt 3):953-70.

PMID: 26912634

1

Desmosterolosis and Desmosterol Homeostasis in the Developing Mouse Brain

Luke B Allen, Thiago C Genaro-Mattos, Ned A Porter, Károly Mirnics, Zeljka Korade

J Inherit Metab Dis. 2019 Sep;42(5):934-943.

PMID: 30891795

1

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated With the Severity of Nonalcoholic Fatty Liver Disease

Hae-Ki Min, Ashwani Kapoor, Michael Fuchs, Faridoddin Mirshahi, Huiping Zhou, James Maher, John Kellum, Russell Warnick, Melissa J Contos, Arun J Sanyal

Cell Metab. 2012 May 2;15(5):665-74.

PMID: 22560219

1

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

Nathanael J Spann, Lana X Garmire, Jeffrey G McDonald, David S Myers, Stephen B Milne, Norihito Shibata, Donna Reichart, Jesse N Fox, Iftach Shaked, Daniel Heudobler, Christian R H Raetz, Elaine W Wang, etc.

Cell. 2012 Sep 28;151(1):138-52.

PMID: 23021221

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