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Didox

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For Research Use Only | Not For Clinical Use
CATAP69839834
CAS69839-83-4
Structure
MDL NumberMFCD01667810
Molecular Weight169.13
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to light brown
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Comparative Effects of Doxorubicin and a Doxorubicin Analog, 13-deoxy, 5-iminodoxorubicin (GPX-150), on Human Topoisomerase IIβ Activity and Cardiac Function in a Chronic Rabbit Model

Nicole E Frank, Barry J Cusack, Todd T Talley, Gerald M Walsh, Richard D Olson

Invest New Drugs. 2016 Dec;34(6):693-700.

PMID: 27581956

1

Didox (3,4-dihydroxybenzohydroxamic Acid) Suppresses IgE-mediated Mast Cell Activation Through Attenuation of NFκB and AP-1 Transcription

Jamie Josephine Avila McLeod, Heather L Caslin, Andrew J Spence, Elizabeth M Kolawole, Amina Abdul Qayum, Anuya Paranjape, Marcela Taruselli, Tamara T Haque, Kasalina N Kiwanuka, Howard L Elford, John J Ryan

Cell Immunol. 2017 Dec;322:41-48.

PMID: 28964543

1

Didox Potentiates the Cytotoxic Profile of Doxorubicin and Protects From Its Cardiotoxicity

Ahmed M Al-Abd, Fahad A Al-Abbasi, Gihan F Asaad, Ashraf B Abdel-Naim

Eur J Pharmacol. 2013 Oct 15;718(1-3):361-9.

PMID: 24021537

1

The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells

Michela Asperti, Luca Cantamessa, Simone Ghidinelli, Magdalena Gryzik, Andrea Denardo, Arianna Giacomini, Giovanna Longhi, Alessandro Fanzani, Paolo Arosio, Maura Poli

Pharmaceuticals (Basel). 2019 Sep 2;12(3):129.

PMID: 31480699

1

The Efficacy of the Ribonucleotide Reductase Inhibitor Didox in Preclinical Models of AML

Guerry J Cook, David L Caudell, Howard L Elford, Timothy S Pardee

PLoS One. 2014 Nov 17;9(11):e112619.

PMID: 25402485

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