CAS 19902-91-1 (+)-Dihydromethysticin - Analytical Products / Alfa Chemistry

CAT	AP19902911-A
CAS	19902-91-1
Structure
MDL Number	MFCD00221731
Molecular Weight	276.28
InChI Key	RSIWXFIBHXYNFM-NSHDSACASA-N
REAXYS Number	91699

Description	analytical standard
Assay	≥90.0% (HPLC)
Form	neat; gas chromatography (GC): suitable
Grade	analytical standard
Impurity Content	≤5.0% water
Size	5MG
Storage Conditions	2-8°C

1

Desmethoxyyangonin and Dihydromethysticin Are Two Major Pharmacological Kavalactones With Marked Activity on the Induction of CYP3A23

Yuzhong Ma, Karuna Sachdeva, Jirong Liu, Michael Ford, Dongfang Yang, Ikhlas A Khan, Clinton O Chichester, Bingfang Yan

Drug Metab Dispos. 2004 Nov;32(11):1317-24.

PMID: 15282211

1

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Sreekanth C Narayanapillai, Linda B von Weymarn, Steven G Carmella, Pablo Leitzman, Jordan Paladino, Pramod Upadhyaya, Stephen S Hecht, Sharon E Murphy, Chengguo Xing

Drug Metab Dispos. 2016 Mar;44(3):422-7.

PMID: 26744252

1

Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O 6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice

Sreekanth C Narayanapillai, Shang-Hsuan Lin, Pablo Leitzman, Pramod Upadhyaya, Carolyn J Baglole, Chengguo Xing

Chem Res Toxicol. 2016 Nov 21;29(11):1828-1834.

PMID: 27728767

1

Monoamine Oxidase Inhibition by Kavalactones From Kava (Piper Methysticum)

Denise Prinsloo, Sandra van Dyk, Anél Petzer, Jacobus P Petzer

Planta Med. 2019 Oct;85(14-15):1136-1142.

PMID: 31539917

1

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O 6-Methylguanine and Lung Tumor in A/J Mice

Manohar Puppala, Sreekanth C Narayanapillai, Pablo Leitzman, Haifeng Sun, Pramod Upadhyaya, M Gerard O'Sullivan, Stephen S Hecht, Chengguo Xing

J Med Chem. 2017 Sep 28;60(18):7935-7940.

PMID: 28806079

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