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Dimethylenastron

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For Research Use Only | Not For Clinical Use
CATAP863774587
CAS863774-58-7
Structure
Molecular Weight302.39
Description≥98% (HPLC)
SolubilityDMSO: 15 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Cell-Based Assay for Mitotic Spindle Orientation

Elina Glaubke, Holger Bastians

Methods Mol Biol. 2018;1787:67-75.

PMID: 29736710

1

Dimethylenastron Suppresses Human Pancreatic Cancer Cell Migration and Invasion in Vitro via Allosteric Inhibition of Mitotic Kinesin Eg5

Xiao-dong Sun, Xing-juan Shi, Xiao-ou Sun, You-guang Luo, Xiao-jing Wu, Chang-fu Yao, Hai-yang Yu, Deng-wen Li, Min Liu, Jun Zhou

Acta Pharmacol Sin. 2011 Dec;32(12):1543-8.

PMID: 21986572

1

Significant Decrease of ADP Release Rate Underlies the Potent Activity of Dimethylenastron to Inhibit Mitotic Kinesin Eg5 and Cancer Cell Proliferation

Linlin Sun, Xiaodong Sun, Songbo Xie, Haiyang Yu, Diansheng Zhong

Biochem Biophys Res Commun. 2014 May 9;447(3):465-70.

PMID: 24732354

1

Structural Basis for Inhibition of Eg5 by Dihydropyrimidines: Stereoselectivity of Antimitotic Inhibitors Enastron, Dimethylenastron and Fluorastrol

Hung Yi Kristal Kaan, Venkatasubramanian Ulaganathan, Oliver Rath, Hana Prokopcová, Doris Dallinger, C Oliver Kappe, Frank Kozielski

J Med Chem. 2010 Aug 12;53(15):5676-83.

PMID: 20597485

1

The Effect of Adjuvant Dimethylenastron, a Mitotic Kinesin Eg5 Inhibitor, in Experimental Glaucoma Filtration Surgery

Julia Lüke, Khaled Nassar, Matthias Lüke, Aycegül Tura, Hartmut Merz, Athanassios Giannis, Salvatore Grisanti

Curr Eye Res. 2010 Dec;35(12):1090-8.

PMID: 20961218

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