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DMXAA

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For Research Use Only | Not For Clinical Use
CATAP117570533
CAS117570-53-3
Structure
MDL NumberMFCD00870555
Molecular Weight282.29
InChI KeyXGOYIMQSIKSOBS-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityDMSO: soluble >10 mg/mL
Assay≥98% (HPLC)
Colorlight brown
Formsolid
Size5MG, 25MG
Storage Conditions2-8°C
1

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Leticia Corrales, Laura Hix Glickman, Sarah M McWhirter, David B Kanne, Kelsey E Sivick, George E Katibah, Seng-Ryong Woo, Edward Lemmens, Tamara Banda, Justin J Leong, Ken Metchette, Thomas W Dubensky Jr, etc.

Cell Rep. 2015 May 19;11(7):1018-30.

PMID: 25959818

1

DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and Like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2'3'-cGAMP, Induces M2 Macrophage Repolarization

Charlene M Downey, Mehrnoosh Aghaei, Reto A Schwendener, Frank R Jirik

PLoS One. 2014 Jun 18;9(6):e99988.

PMID: 24940883

1

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

Xianjun Luo, Honggui Li, Linqiang Ma, Jing Zhou, Xin Guo, Shih-Lung Woo, Ya Pei, Linda R Knight, Michael Deveau, Yanming Chen, Xiaoxian Qian, Xiaoqiu Xiao, Qifu Li, Xiangbai Chen, Yuqing Huo, Kelly McDaniel, etc.

Gastroenterology. 2018 Dec;155(6):1971-1984.e4.

PMID: 30213555

1

STING-mediated Intestinal Barrier Dysfunction Contributes to Lethal Sepsis

Qiongyuan Hu, Huajian Ren, Guanwei Li, Dingyu Wang, Quan Zhou, Jie Wu, Jiashuo Zheng, Jinjian Huang, Dominic A Slade, Xiuwen Wu, Jianan Ren

EBioMedicine. 2019 Mar;41:497-508.

PMID: 30878597

1

TGFβ Blocks IFNα/β Release and Tumor Rejection in Spontaneous Mammary Tumors

Marion V Guerin, Fabienne Regnier, Vincent Feuillet, Lene Vimeux, Julia M Weiss, Georges Bismuth, Gregoire Altan-Bonnet, Thomas Guilbert, Maxime Thoreau, Veronica Finisguerra, Emmanuel Donnadieu, Alain Trautmann, etc.

Nat Commun. 2019 Sep 11;10(1):4131.

PMID: 31511510

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