CAS 99873-43-5 Droxinostat - Analytical Products / Alfa Chemistry

CAT	AP99873435
CAS	99873-43-5
Structure
MDL Number	MFCD01326592
Molecular Weight	243.69
InChI Key	JHSXDAWGLCZYSM-UHFFFAOYSA-N

Description	≥98% (HPLC)
Solubility	DMSO: ≥20 mg/mL
Assay	≥98% (HPLC)
Color	white to off-white
Form	powder
Size	5MG, 25MG
Storage Conditions	2-8°C

1

Droxinostat Sensitizes Human Colon Cancer Cells to Apoptotic Cell Death via Induction of Oxidative Stress

Ying Huang, Wuping Yang, Huihong Zeng, Chuan Hu, Yaqiong Zhang, Nanhua Ding, Guangqin Fan, Lijian Shao, Bohai Kuang

Cell Mol Biol Lett. 2018 Jul 28;23:34.

PMID: 30065760

1

Droxinostat, a Histone Deacetylase Inhibitor, Induces Apoptosis in Hepatocellular Carcinoma Cell Lines via Activation of the Mitochondrial Pathway and Downregulation of FLIP

Jing Liu, Guangming Li, Xiang Wang, Liang Wang, Rui Zhao, Juanxia Wang, Yin Kong, Jie Ding, Juan Li, Lingyi Zhang

Transl Oncol. 2016 Feb;9(1):70-78.

PMID: 26947884

1

MGCD0103, a Selective Histone Deacetylase Inhibitor, Coameliorates Oligomeric Aβ

Hei-Jen Huang, Hsin-Yu Huang, Hsiu Mei Hsieh-Li

CNS Neurosci Ther. 2019 Feb;25(2):175-186.

PMID: 29978554

1

Phosphorylation of Histone Deacetylase 8: Structural and Mechanistic Analysis of the Phosphomimetic S39E Mutant

Katherine R Welker Leng, Carol Ann Castañeda, Christophe Decroos, Barira Islam, Shozeb M Haider, David W Christianson, Carol A Fierke

Biochemistry. 2019 Nov 12;58(45):4480-4493.

PMID: 31633931

1

Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands

Tabitha E Wood, Shadi Dalili, Craig D Simpson, Mahadeo A Sukhai, Rose Hurren, Kika Anyiwe, Xinliang Mao, Fernando Suarez Saiz, Marcela Gronda, Yanina Eberhard, Neil MacLean, Troy Ketela, John C Reed, Jason Moffat, etc.

Mol Cancer Ther. 2010 Jan;9(1):246-56.

PMID: 20053768

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