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E-4031

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For Research Use Only | Not For Clinical Use
CATAP113559130
CAS113559-13-0
Structure
MDL NumberMFCD01754739
Molecular Weight474.44
InChI KeyZQBNWMFBOSOOLX-UHFFFAOYSA-N
Description≥98% (HPLC), solid
SolubilityH2O: soluble
Assay≥98% (HPLC)
Coloroff-white
Formsolid
Size0.1MG, 0.5MG, 1MG
Storage Conditions−20°C
1

Analysis of Torsadogenic and Pharmacokinetic Profile of E-4031 in Dogs Bridging the Gap of Information Between in Vitro Proarrhythmia Assay and Clinical Observation in Human Subjects

Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T Naito, Atsushi Sugiyama

J Pharmacol Sci. 2018 Jun;137(2):237-240.

PMID: 29980434

1

Dissociation of E-4031 From the HERG Channel Caused by Mutations of an Amino Acid Results in Greater Block at High Stimulation Frequency

Kuniaki Ishii, Mirei Nagai, Masahiro Takahashi, Masao Endoh

Cardiovasc Res. 2003 Mar;57(3):651-9.

PMID: 12618227

1

E 4031

Drugs R D. 1999 Apr;1(4):312-6.

PMID: 10566051

1

Effects of Bepridil Versus E-4031 on Transmural Ventricular Repolarization and Inducibility of Ventricular Tachyarrhythmias in the Dog

Daisuke Izumi, Masaomi Chinushi, Kenichi Iijima, Shizue Ahara, Satoru Komura, Hiroshi Furushima, Yukio Hosaka, Akiko Sanada, Nobue Yagihara, Yoshifusa Aizawa

Pacing Clin Electrophysiol. 2010 Aug;33(8):950-9.

PMID: 20487341

1

Postnatal Development of E-4031-sensitive Potassium Current in Rat Carotid Chemoreceptor Cells

Insook Kim, Kathleen M Boyle, John L Carroll

J Appl Physiol (1985). 2005 Apr;98(4):1469-77.

PMID: 15591286

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