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EAA-090

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For Research Use Only | Not For Clinical Use
CATAP144912630
CAS144912-63-0
MDL NumberMFCD00912427
Molecular Weight260.18
InChI KeyBDABGOLMYNHHTR-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityH2O: ≥2 mg/mL
Assay≥98% (HPLC)
Colorlight yellow to yellow
Formpowder
Size10MG, 50MG
Storage Conditions2-8°C
1

Characterization of Two Novel N-methyl-D-aspartate Antagonists: EAA-090 (2-[8,9-dioxo-2,6-diazabicyclo [5.2.0]non-1(7)-en2-yl]ethylphosphonic Acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoic Acid Hydrochloride)

Lucy Sun, Doreen Chiu, Dianne Kowal, Rachelle Simon, Michelle Smeyne, R Suzanne Zukin, John Olney, Reinhardt Baudy, Stephen Lin

J Pharmacol Exp Ther. 2004 Aug;310(2):563-70.

PMID: 15075380

1

Design and Synthesis of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic Acid (EAA-090), a Potent N-methyl-D-aspartate Antagonist, via the Use of 3-cyclobutene-1,2-dione as an Achiral Alpha-Amino Acid Bioisostere

W A Kinney, M Abou-Gharbia, D T Garrison, J Schmid, D M Kowal, D R Bramlett, T L Miller, R P Tasse, M M Zaleska, J A Moyer

J Med Chem. 1998 Jan 15;41(2):236-46.

PMID: 9457246

1

Effects of the N-methyl-D-aspartate Receptor Antagonist Perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic Acid] on Chemically Induced Thermal Hypersensitivity

Michael R Brandt, Terri A Cummons, Lisa Potestio, Stacey J Sukoff, Sharon Rosenzweig-Lipson

J Pharmacol Exp Ther. 2005 Jun;313(3):1379-86.

PMID: 15764736

1

Pharmacological Characterization of Antiepileptic Drugs and Experimental Analgesics on Low Magnesium-Induced Hyperexcitability in Rat Hippocampal Slices

Robert L Arias, Mark R Bowlby

Brain Res. 2005 Jun 21;1047(2):233-44.

PMID: 15907811

1

Role of GluN2A and GluN2B Subunits in the Formation of Filopodia and Secondary Dendrites in Cultured Hippocampal Neurons

Frank Henle, Martina Dehmel, Jost Leemhuis, Catharina Fischer, Dieter K Meyer

Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb;385(2):171-80.

PMID: 22033802

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