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Ellipticine - CAS 519-23-3

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For Research Use Only | Not For Clinical Use
CATAP519233
CAS519-23-3
Structure
Molecular Weight246.31
DescriptionA cell-permeable antitumor alkaloid that acts as an inhibitor of topoisomerase II and acts as an intercalative agent that stimulates topoisomerase II-mediated DNA breakage.
Solubilityethanol: 1 mg/mL; DMSO: 5 mg/mL
Assay≥99% (HPLC)
Colorbright yellow
Formsolid
Size10MG
Storage Conditions+2C to +8C
1

Interaction Effects of 5-azacytidine With Topoisomerase II Inhibitors on CHO Cells, as Detected by Cytogenetic Analysis

S A Takahashi-Hyodo, E T Sakamoto-Hojo, C S Takahashi

Mutat Res. 1999 Dec 16;431(1):13-23.

PMID: 10656482

1

Sister-chromatid Exchanges, Chromosomal Aberrations and Cytotoxicity Produced by Topoisomerase II-targeted Drugs in Sensitive (A2780) and Resistant (A2780-DX3) Human Ovarian Cancer Cells: Correlations With the Formation of DNA Double-Strand Breaks

E Noviello, M G Aluigi, G Cimoli, E Rovini, A Mazzoni, S Parodi, F De Sessa, P Russo

Mutat Res. 1994 Nov 1;311(1):21-9.

PMID: 7526171

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