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ELND006

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For Research Use Only | Not For Clinical Use
CATAP1333990843
CAS1333990-84-3
MDL NumberMFCD28386354
Molecular Weight455.40
Description≥98% (HPLC)
SolubilityDMSO: 2 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Formulation Strategy for Gamma Secretase Inhibitor ELND006, a BCS Class II Compound: Development of a Nanosuspension Formulation With Improved Oral Bioavailability and Reduced Food Effects in Dogs

Kevin Quinn, Rampurna Prasad Gullapalli, Elaine Merisko-Liversidge, Erich Goldbach, Angelina Wong, Gary G Liversidge, Wherly Hoffman, John-Michael Sauer, John Bullock, George Tonn

J Pharm Sci. 2012 Apr;101(4):1462-74.

PMID: 22213574

1

ACS Chemical Neuroscience Molecule Spotlight on ELND006: Another γ-secretase Inhibitor Fails in the Clinic

Corey R Hopkins

ACS Chem Neurosci. 2011 Jun 15;2(6):279-80.

PMID: 22778871

1

Development of ALZET® Osmotic Pump Compatible Solvent Compositions to Solubilize Poorly Soluble Compounds for Preclinical Studies

Rampurna Gullapalli, Angelina Wong, Elizabeth Brigham, Grace Kwong, Angie Wadsworth, Christopher Willits, Kevin Quinn, Erich Goldbach, Bhushan Samant

Drug Deliv. Jun-Jul 2012;19(5):239-46.

PMID: 22656673

1

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): Metabolically Stable γ-secretase Inhibitors That Selectively Inhibit the Production of amyloid-β Over Notch

Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Roy K Hom, Andrei W Konradi, Jennifer L Marugg, Matthew N Mattson, Martin L Neitzel, Chris M Semko, Hing L Sham, Jenifer Smith, etc.

J Med Chem. 2013 Jul 11;56(13):5261-74.

PMID: 23713656

1

Long-term Effect of Neonatal Inhibition of APP Gamma-Secretase on Hippocampal Development in the Ts65Dn Mouse Model of Down Syndrome

Fiorenza Stagni, Alessandra Raspanti, Andrea Giacomini, Sandra Guidi, Marco Emili, Elisabetta Ciani, Alessandro Giuliani, Andrea Bighinati, Laura Calzà, Jacopo Magistretti, Renata Bartesaghi

Neurobiol Dis. 2017 Jul;103:11-23.

PMID: 28359846

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