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EMD-87580

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For Research Use Only | Not For Clinical Use
CATAP187870786
CAS187870-78-6
Molecular Weight333.38
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions−20°C
1

Cardioprotective Efficacy Against Reperfusion Injury of EMD-87580: Comparison to Ischemic Postconditioning

Juliana Fantinelli, Luisa F González Arbeláez, Susana M Mosca

Eur J Pharmacol. 2014 Aug 15;737:125-32.

PMID: 24858370

1

Improved Myocardial Function Using a Na+/H+ Exchanger Inhibitor During Cardioplegic Arrest and Cardiopulmonary Bypass

Charles S Cox Jr, Steven J Allen, Henning Sauer, Glen A Laine

Chest. 2003 Jan;123(1):187-94.

PMID: 12527621

1

Inhibition of Na +/H + Exchanger With EMD 87580 does not Confer Greater Cardioprotection Beyond Preconditioning on Ischemia-Reperfusion Injury in Normal Dogs

J G Kingma

J Cardiovasc Pharmacol Ther. 2018 May;23(3):254-269.

PMID: 29562750

1

NHE-1 Inhibition Improves Cardiac Mitochondrial Function Through Regulation of Mitochondrial Biogenesis During Postinfarction Remodeling

Sabzali Javadov, Daniel M Purdham, Asad Zeidan, Morris Karmazyn

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1722-30.

PMID: 16679399

1

Optimal Dose and Mode of Delivery of Na+/H+ exchange-1 Inhibitor Are Critical for Reducing Postsurgical Ischemia-Reperfusion Injury

Joel S Corvera, Zhi-Qing Zhao, L Susan Schmarkey, Sara L Katzmark, Jason M Budde, Cullen D Morris, Thomas Ehring, Robert A Guyton, Jakob Vinten-Johansen

Ann Thorac Surg. 2003 Nov;76(5):1614-22.

PMID: 14602297

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