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Epoxomicin, Synthetic

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For Research Use Only | Not For Clinical Use
CATIAR42410900
Molecular Weight554.72
DescriptionEpoxomicin, Synthetic, CAS 134381-21-8, is a potent, specific, and irreversible inhibitor of chymotrypsin-like, trypsin-like, and peptidyl-glutamyl peptide hydrolyzing activities of the proteasome.
SolubilityDMSO: 1 mg/mL; methanol: 1 mg/mL
Assay≥95% (HPLC)
Colorwhite
Formsolid; protect from light
Size100μG
Storage Conditions-20C
1

Developing Natural Product Drugs: Supply Problems and How They Have Been Overcome

David J Newman

Pharmacol Ther. 2016 Jun;162:1-9.

PMID: 26706239

1

Development and Characterization of Proteasome Inhibitors

Kyung Bo Kim, Fabiana N Fonseca, Craig M Crews

Methods Enzymol. 2005;399:585-609.

PMID: 16338383

1

From Epoxomicin to Carfilzomib: Chemistry, Biology, and Medical Outcomes

Kyung Bo Kim, Craig M Crews

Nat Prod Rep. 2013 May;30(5):600-4.

PMID: 23575525

1

SPR Imaging Biosensor for the 20S Proteasome: Sensor Development and Application to Measurement of Proteasomes in Human Blood Plasma

Ewa Gorodkiewicz, Halina Ostrowska, Anna Sankiewicz

Mikrochim Acta. 2011 Oct;175(1-2):177-184.

PMID: 21966027

1

Systemic Exposure to Proteasome Inhibitors Causes a Progressive Model of Parkinson's Disease

Kevin St P McNaught, Daniel P Perl, Anna-Liisa Brownell, C Warren Olanow

Ann Neurol. 2004 Jul;56(1):149-62.

PMID: 15236415

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