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EPZ015666

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For Research Use Only | Not For Clinical Use
CATAP1616391651
CAS1616391-65-1
MDL NumberMFCD28411588
Molecular Weight383.44
InChI KeyZKXZLIFRWWKZRY-KRWDZBQOSA-N
Description≥98% (HPLC)
SolubilityDMSO: 20 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

A Selective Inhibitor of PRMT5 With in Vivo and in Vitro Potency in MCL Models

Elayne Chan-Penebre, Kristy G Kuplast, Christina R Majer, P Ann Boriack-Sjodin, Tim J Wigle, L Danielle Johnston, Nathalie Rioux, Michael J Munchhof, Lei Jin, Suzanne L Jacques, Kip A West, Trupti Lingaraj, etc.

Nat Chem Biol. 2015 Jun;11(6):432-7.

PMID: 25915199

1

Protein Arginine Methyltransferase 5 Has Prognostic Relevance and Is a Druggable Target in Multiple Myeloma

A Gullà, T Hideshima, G Bianchi, M Fulciniti, M Kemal Samur, J Qi, Y-T Tai, T Harada, E Morelli, N Amodio, R Carrasco, P Tagliaferri, N C Munshi, P Tassone, K C Anderson

Leukemia. 2018 Apr;32(4):996-1002.

PMID: 29158558

1

Role of Protein Arginine Methyltransferase 5 in Group 3 (MYC-driven) Medulloblastoma

Nagendra K Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R McGuire, J Graham Sharp, Shantaram S Joshi, Don W Coulter

BMC Cancer. 2019 Nov 6;19(1):1056.

PMID: 31694585

1

Role of Protein Arginine Methyltransferase 5 in Inflammation and Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis

Dongying Chen, Shan Zeng, Mingcheng Huang, Hanshi Xu, Liuqin Liang, Xiuyan Yang

J Cell Mol Med. 2017 Apr;21(4):781-790.

PMID: 27860244

1

The Protein Arginine Methyltransferase PRMT5 Confers Therapeutic Resistance to mTOR Inhibition in Glioblastoma

Brent Holmes, Angelica Benavides-Serrato, Jacquelyn T Saunders, Kenna A Landon, Adam J Schreck, Robert N Nishimura, Joseph Gera

J Neurooncol. 2019 Oct;145(1):11-22.

PMID: 31473880

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