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EX-527

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For Research Use Only | Not For Clinical Use
CATAP49843983-A
CAS49843-98-3
MDL NumberMFCD03009471
Molecular Weight248.71
InChI KeyFUZYTVDVLBBXDL-UHFFFAOYSA-N
Description≥98% (HPLC)
SolubilityDMSO: >20 mg/mL
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C
1

Ex-527 Inhibits Sirtuins by Exploiting Their Unique NAD+-dependent Deacetylation Mechanism

Melanie Gertz, Frank Fischer, Giang Thi Tuyet Nguyen, Mahadevan Lakshminarasimhan, Mike Schutkowski, Michael Weyand, Clemens Steegborn

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2772-81.

PMID: 23840057

1

Protective Effect of EX-527 Against High-Fat Diet-Induced Diabetic Nephropathy in Zucker Rats

Amit Kundu, Sachan Richa, Prasanta Dey, Kyeong Seok Kim, Ji Yeon Son, Hae Ri Kim, Seok-Yong Lee, Byung-Hoon Lee, Kwang Youl Lee, Sam Kacew, Byung Mu Lee, Hyung Sik Kim

Toxicol Appl Pharmacol. 2020 Mar 1;390:114899.

PMID: 31981641

1

Protective Effects of ex-527 on Cerebral Ischemia-Reperfusion Injury Through Necroptosis Signaling Pathway Attenuation

Sara Nikseresht, Fariba Khodagholi, Abolhassan Ahmadiani

J Cell Physiol. 2019 Feb;234(2):1816-1826.

PMID: 30067864

1

Small Molecules as SIRT Modulators

Xinfa Bai, Lei Yao, Xuan Ma, Xiangming Xu

Mini Rev Med Chem. 2018;18(13):1151-1157.

PMID: 27334466

1

The SIRT1 Inhibitor EX-527 Suppresses mTOR Activation and Alleviates Acute Lung Injury in Mice With Endotoxiemia

Jing Huang, Rui Tian, Yongqiang Yang, Rong Jiang, Jie Dai, Li Tang, Li Zhang

Innate Immun. 2017 Nov;23(8):678-686.

PMID: 28952835

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